First-phase insulin secretion

1. Saxagliptin increases first-phase insulin secretion in humans (p < 0.05).

   “In treatment-specific analyses, MET, SAXA and PIO increased first-phase ISecr at 2 years (p < 0.05).”

   Human trialprediabetes2 yearsn = 15

   Long-Term Impact of Early Oral Antidiabetic Therapy on Insulin Secretion Phases in Individuals with Prediabetes (PreDM): Insights from Hyperglycemic Clamp Studies

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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1. Pioglitazone increases first-phase insulin secretion in humans (p < 0.05).

   “In treatment-specific analyses, MET, SAXA and PIO increased first-phase ISecr at 2 years (p < 0.05).”

   Human trialprediabetes2 yearsn = 15

   Long-Term Impact of Early Oral Antidiabetic Therapy on Insulin Secretion Phases in Individuals with Prediabetes (PreDM): Insights from Hyperglycemic Clamp Studies

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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1. Metformin increases first-phase insulin secretion in humans (p < 0.05).

   “In treatment-specific analyses, MET, SAXA and PIO increased first-phase ISecr at 2 years (p < 0.05).”

   Human trialprediabetes2 yearsn = 15

   Long-Term Impact of Early Oral Antidiabetic Therapy on Insulin Secretion Phases in Individuals with Prediabetes (PreDM): Insights from Hyperglycemic Clamp Studies

   ADA Scientific Sessions 2026 abstract·5 Jun 2026

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1. Alanine aminotransferase is associated with first-phase insulin secretion in humans.

   “The correlation and the linear regression model showed that increasing ALT level was significantly correlated with higher log-transformed FPIS and SPIS.”

   Humanshealthy elderly Han Chinese individuals; log-transformed secretionn = 39,845

   Elevated alanine aminotransferase is associated with biphasic insulin secretion in the healthy elderly Han Chinese population

   The Journal of international medical research·1 Sep 2022

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