Fibroblast aging program

Fibroblast aging program is associated with patient outcomes in humans.

“the fibroblast aging program as the most prominent stromal signature, with higher program activity being associated with poor patient outcomes”

Humansmelanoma; age-adjusted survival analysisskin

Integrated single-cell and spatial transcriptomic analyses reveal an aging-associated fibroblast subtype linked to tumor progression in human skin

Frontiers in medicine·8 Jul 2026