Expanded phenotypic age
1 paper4 findings
- Humans1
Interventions
2Smoking
mediatesin humans1
1 study
Smoking
mediatesin humans1
Smoking mediates expanded phenotypic age in humans (8.5% of total effect).
“Among behavioral pathways, physical activity (20.3 %), smoking (8.5 %) and poor sleep quality (7.1 %) each accounted for a meaningful portion of the total effect.”
Humansmediating social isolation and accelerated biological aging2006 to 2016n = 4,036
Social science & medicine (1982)12 Dec 2025
Physical activity
mediatesin humans1
1 study
Physical activity
mediatesin humans1
Physical activity mediates expanded phenotypic age in humans (20.3% of total effect).
“Among behavioral pathways, physical activity (20.3 %), smoking (8.5 %) and poor sleep quality (7.1 %) each accounted for a meaningful portion of the total effect.”
Humansmediating social isolation and accelerated biological aging2006 to 2016n = 4,036
Social science & medicine (1982)12 Dec 2025
Upstream
1Depressive symptoms
mediatesin humans1
1 study
Depressive symptoms
mediatesin humans1
Depressive symptoms mediate expanded phenotypic age in humans (7.7% of association).
“Depressive symptoms explained about 7.7 % of the association, whereas drinking did not demonstrate a significant mediating effect.”
Humansmediating social isolation and accelerated biological aging2006 to 2016n = 4,036
Social science & medicine (1982)12 Dec 2025
Associations
1Social isolation
upin humans1
1 study
Social isolation
upin humans1
Social isolation is associated with expanded phenotypic age in humans.
“Social isolation was longitudinally associated with accelerated biological aging after adjusting for sociodemographic, health, and psychosocial confounders.”
Humans2006 to 2016n = 4,036
Social science & medicine (1982)12 Dec 2025