What does the research say about erythrocyte volume?

Erythrocyte volume

There are 4 papers on erythrocyte volume in aging research: 2 observational studies in people, 1 in animals, 1 in cells. The newest story, Nov 2, 2026: “Disease-linked DNA variants show signs of natural selection”.

Biomarker

4 papers study it7 more mention it2 findings

1 new paper in 30 daysSee all 11 papers on erythrocyte volume

Humans2
Animals1
Cells1

Upstream

Candidate variant subset

upin humans1

1 study

candidate variant subset is linked with higher erythrocyte volume in humans (phenome-wide association analysis across 30 hematologic and cardiometabolic traits).
“Phenome-wide association analysis across 30 hematologic and cardiometabolic traits linked a subset of candidates to increased erythrocyte volume and reduced hemoglobin concentration”
Humansphenome-wide association analysis across 30 hematologic and cardiometabolic traits
Disease-linked DNA variants show signs of natural selection
American journal of human geneticsJul 24, 2026

Associations

Erythrocyte aging

downin rats1

1 study

Erythrocyte aging is associated with erythrocyte volume in rats.
“Red cell aging was associated with a decline in cell volume, haemoglobin, G6PD and ATP content.”
Animalserythrocyte
Observations on the in vivo aging of red cells in the rat
Scandinavian journal of haematologyJun 1, 1975

Latest

2 papers in 12 months

bioRxivOct 29

Erythrocyte aging links hypocalcemia to impaired flow dynamics and oxygen transport through volume dysregulation

Preprint: experiments in cellsMechanisms

Paper

American Journal of Human GeneticsJul 25

Disease-linked DNA variants show signs of natural selection

An observational analysis of 72,635 Han Taiwanese adults identified 168 DNA variants with age-group differences consistent with ongoing natural selection.An observational analysis of 72,635 Han Taiwanese adults identified 168 DNA variants with age-group differences consistent with ongoing natural selection.

Cross-sectional · 72,635 peopleMechanisms