American Journal of Human Genetics
Disease-linked DNA variants show signs of natural selection
An observational analysis of 72,635 Han Taiwanese adults identified 168 DNA variants with age-group differences consistent with ongoing natural selection.An observational analysis of 72,635 Han Taiwanese adults identified 168 DNA variants with age-group differences consistent with ongoing natural selection.
Cross-sectional · 72,635 peopleMechanisms
Who was studied72,635 Han Taiwanese individuals
What changedOf 168 candidate variants, 159 were less common in younger generations
The catchSelection was inferred from age groups; genetic changes across generations were not followed