ECG age acceleration

1. Cardiovascular disease is associated with ECG age acceleration in humans.

   “Diseased subjects exhibited significant positive age acceleration across multiple categories, with structural and ischemic heart diseases showing the largest effects.”

   Humans

   ECG-derived age deviation predicts cardiovascular diseases across lead configurations and cohorts

   medRxiv·8 Jun 2026Preprint

More on Cardiovascular disease

1. ECG age acceleration predicts mortality in humans.

   “External validation in a hospital-based cohort (n=160,493) confirmed that age acceleration independently predicts all-cause mortality”

   Humans

   ECG-derived age deviation predicts cardiovascular diseases across lead configurations and cohorts

   medRxiv·8 Jun 2026Preprint

1. ECG age acceleration is associated with cognitive function in humans (β = -0.02, 95% CI: -0.03, -0.02).

   “higher Δage was associated with lower global cognitive performance (UKB: β = -0.02, 95% CI: -0.03, -0.02”

   Humansn = 59,213

   Association between electrocardiographic age and cognitive function: findings from the UK biobank and Framingham Heart Study

   European heart journal. Digital health·18 Feb 2026