DunedinPACNI

1. DunedinPACNI predicts chronic disease in humans (HR = 1.14, p = 0.01).

   “disease risk (HR = 1.14, p = 0.01), and mortality risk (HR = 1.32, p < 0.001).”

   Humansn = 42,583

   An estimate of the pace of aging from a single brain scan predicts chronic disease, dementia, and mortality · GSA 2025 abstract · 31 Dec 2025

Chronic disease →

1. DunedinPACNI is associated with frailty in humans (β = 0.17, p < 0.001).

   “In 42,583 UK Biobank participants, people with faster DunedinPACNI also had greater hippocampal atrophy (β=-0.09; p < 0.001), frailty (β = 0.17; p < 0.001)”

   Humansn = 42,583

   An estimate of the pace of aging from a single brain scan predicts chronic disease, dementia, and mortality · GSA 2025 abstract · 31 Dec 2025

1. DunedinPACNI predicts mortality in humans (HR = 1.32, p < 0.001).

   “In 42,583 UK Biobank participants, people with faster DunedinPACNI also had greater hippocampal atrophy (β=-0.09; p < 0.001), frailty (β = 0.17; p < 0.001), disease risk (HR = 1.14, p = 0.01), and mortality risk (HR = 1.32, p < 0.001).”

   Humansn = 42,583

   An estimate of the pace of aging from a single brain scan predicts chronic disease, dementia, and mortality · GSA 2025 abstract · 31 Dec 2025

1. DunedinPACNI predicts dementia in humans (HR = 1.76, p < 0.001).

   “In 1,737 ADNI participants, people with faster DunedinPACNI had greater cognitive impairment (MCI: β = 0.27; p < 0.001; AD: β = 0.81; p < 0.001) dementia risk (HR = 1.76, p < 0.001)”

   Humansn = 1,737

   An estimate of the pace of aging from a single brain scan predicts chronic disease, dementia, and mortality · GSA 2025 abstract · 31 Dec 2025

Dementia →