DNAm GrimAge acceleration

1. DNAm GrimAge acceleration is associated with incident atrial fibrillation in humans (Adjusted HR 1.19 (95% CI 1.09–1.31) per 5-year increase).

   “Five-year increases in EAA measures for DNAm GrimAge and DNAm PhenoAge were associated with 19% (adjusted hazard ratio [HR], 1.19 [95% CI, 1.09-1.31]; P<0.01)”

   HumansMultivariable adjustment for chronological age and AF risk factors5-year increase in epigenetic age accelerationMean follow-up of 12.9 yearsFemale, 60.1%sn = 5,600

   Epigenetic Age and the Risk of Incident Atrial Fibrillation

   Circulation·30 Sep 2021

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