DNA methylation at candidate circadian gene loci

1. Sleep restriction increases DNA methylation at candidate circadian gene loci in humans.

   “All but one (cg23738833) showed hypermethylation after SR vs AS.”

   Human trialHealthy adults; sleep restriction compared with habitual adequate sleepperipheral blood cell-1.5 h/night6 weeks65% womensn = 60

   Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial

   Aging and disease·21 Mar 2026

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