DNA binding

Biomarker

1 paper1 finding

Cells1

Associations

DNMT3A

mixedin human cells1

1 study

DNMT3A is associated with DNA binding in human cells.
Cellsmutations from all disease classes
Disease mutations in the PWWP domain of DNMT3A affect chromatin recruitment through multiple mechanisms
bioRxiv31 Aug 2026Preprint

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Cell Death Discovery7 Oct

New protein form pushed lab-grown cells to stop dividing

Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.Cell experiments identified a previously unknown protein form that responded to DNA damage and triggered senescence, a state in which cells stop dividing.

Experiments in cellsMechanisms

Paper

bioRxiv30 Sep

Early social isolation accelerates TDP-43 pathology in flies

Young adult fruit flies housed alone showed faster retrovirus activation, accelerated spread of glial TDP-43 to neurons, and shortened lifespan compared to group-housed…Young adult fruit flies housed alone showed faster retrovirus activation, accelerated spread of glial TDP-43 to neurons, and shortened lifespan compared to group-housed flies.

Preprint: experiments in fliesMechanisms

Paper

Alzheimer's & Dementia16 Sep