Digital AS Severity index

Digital AS Severity index is associated with mortality in humans (HR 1.17 [95%CI: 1.10-1.25]).

“AI-ECG score (HR 1.08 [95%CI: 1.01-1.15]) and DASSi (1.17 [1.10-1.25]), but not peak velocity (1.04 [0.98-1.10]) were associated with mortality”

Humansmedian follow-up of 4.6 yearsn = 61,812

Multimodal AI Signatures of Cardiac Remodeling Independently Predict Worse Aortic Stenosis Prognosis

AHA Scientific Sessions 2025 abstract·3 Nov 2025

Digital AS Severity index predicts incident aortic valve replacement in humans (HR 2.56 [95%CI: 2.03-3.25] per 1 SD).

“All 3 biomarkers independently predicted AS progression based on incident AVR (per 1 SD: 2.56 [95%CI: 2.16-3.04], 2.56 [2.03-3.25] and 1.61 [1.24-2.08], respectively)”

Humansmedian follow-up of 4.6 yearsn = 61,812

Multimodal AI Signatures of Cardiac Remodeling Independently Predict Worse Aortic Stenosis Prognosis

AHA Scientific Sessions 2025 abstract·3 Nov 2025