Diffusing capacity for carbon monoxide

1. Diffusing capacity for carbon monoxide increases frailty in humans (OR 4.44 (95%CI: 1.81, 10.93)).

   “4.44-fold (95%CI: 1.81, 10.93) greater odds of frailty compared to participants with normal DLCO”

   Humansmalesn = 1,048

   Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS)

   Annals of epidemiology·Oct 14, 2022

1. Diffusing capacity for carbon monoxide impairs gait speed in humans (-0.04 m/sec (95%CI: -0.06, -0.02)).

   “0.04 m/sec (95%CI: -0.06, -0.02) slower gait speed”

   Humansmalesn = 1,048

   Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS)

   Annals of epidemiology·Oct 14, 2022

1. Diffusing capacity for carbon monoxide impairs grip strength in humans (-3.5 kg (95%CI: -4.6, -2.4)).

   “Participants with impaired DLCO had 3.5 kg (95%CI: -4.6, -2.4) weaker grip strength”

   Humansmalesn = 1,048

   Pulmonary and physical function limitations in aging men with and without HIV from the Multicenter AIDS Cohort Study (MACS)

   Annals of epidemiology·Oct 14, 2022

1. Gait speed is associated with diffusing capacity for carbon monoxide in humans.

   “Slow gait speed was associated with higher odds of DLCO impairment but not FEV1.”

   Humans3 yearsmalesn = 1,024

   Frailty, Physical Function Impairment and Pulmonary Function in Aging Men with and without HIV from the Multicenter AIDS Cohort Study (MACS)

   Research square·Sep 10, 2024Preprint

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