Dextromethorphan systemic exposure

1. Microbiota clearance decreases dextromethorphan systemic exposure in mice.

   “age-related increase in DEX exposure in the old mice could be reversed by clearance of microbiota”

   Animalsclearance of microbiota

   Gut microbiota influence pharmacokinetics variability in aging mice: Effects vary from drug to drug

   Drug metabolism and disposition: the biological fate of chemicals·21 Jan 2026

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