D3Cr muscle mass

1. FSTL3 is associated with D3Cr muscle mass in humans (r < -0.25, adjusted p < 6x10^(-6)).

   “Leptin and FSTL3 were negatively correlated with D3Cr muscle mass (r<-0.25, adjusted p < 6x10^(-6) for both)”

   Humansmales

   Proteomic Determinants of Muscle Size in Older Men: The Osteoporotic Fractures in Men Study

   GSA 2025 abstract·Dec 31, 2025

More on FSTL3

1. LEP is associated with D3Cr muscle mass in humans (r < -0.25, adjusted p < 6x10^(-6)).

   “Leptin and FSTL3 were negatively correlated with D3Cr muscle mass (r<-0.25, adjusted p < 6x10^(-6) for both)”

   Humansmales

   Proteomic Determinants of Muscle Size in Older Men: The Osteoporotic Fractures in Men Study

   GSA 2025 abstract·Dec 31, 2025

More on LEP

1. SVEP1 is associated with D3Cr muscle mass in humans (r < -0.23, adjusted p < 3x10^(-7)).

   “significant negative correlations between D3Cr muscle mass and SVEP1 (protein with a role in vascular disease) and brorin (a bone morphogenic protein) (r<-0.23, adjusted p < 3x10^(-7) for all)”

   Humansmales

   Proteomic Determinants of Muscle Size in Older Men: The Osteoporotic Fractures in Men Study

   GSA 2025 abstract·Dec 31, 2025

More on SVEP1

1. CKM is associated with D3Cr muscle mass in humans (r > 0.34, adjusted p < 3x10^(-10)).

   “significant positive associations between D3Cr muscle mass with creatine kinase M type, and creatine kinase M type:B type heterodimer (r > 0.34, adjusted p < 3x10^(-10) for both)”

   Humansmales

   Proteomic Determinants of Muscle Size in Older Men: The Osteoporotic Fractures in Men Study

   GSA 2025 abstract·Dec 31, 2025

More on CKM

1. ALPHA-HYDROXY-5-METHYL-TETRAHYDROFOLATE is associated with D3Cr muscle mass in humans (r = -0.25, p < .001).

   “For D3Cr muscle mass, significant biomarkers (p < .001) with ≥10% fold difference and largest partial correlations were tryptophan (Trp; r = 0.31), kynurenine (Kyn)/Trp; r = -0.27), nicotinamide (Nam)/quinolinic acid (Quin; r = 0.21), and alpha-hydroxy-5-methyl-tetrahydrofolate (hm-THF; r = -0.25).”

   Humansplasmamales

   Nutrient Metabolites Associated With Low D3Cr Muscle Mass, Strength, and Physical Performance in Older Men

   The journals of gerontology. Series A, Biological sciences and medical sciences·Sep 11, 2023

More on ALPHA-HYDROXY-5-METHYL-TETRAHYDROFOLATE

1. Tryptophan is associated with D3Cr muscle mass in humans (r = 0.31, p < .001).

   “For D3Cr muscle mass, significant biomarkers (p < .001) with ≥10% fold difference and largest partial correlations were tryptophan (Trp; r = 0.31)”

   Humansplasmamales

   Nutrient Metabolites Associated With Low D3Cr Muscle Mass, Strength, and Physical Performance in Older Men

   The journals of gerontology. Series A, Biological sciences and medical sciences·Sep 11, 2023

More on Tryptophan