Proteomic Determinants of Muscle Size in Older Men: The Osteoporotic Fractures in Men Study

Abstract

In MrOS, men with low muscle mass as determined by deuterated creatine dilution (D3Cr muscle mass) are weaker, slower, and have a higher risk of incident falls, mobility limitation, disability, fractures and death. Proteomic determinants of D3Cr muscle mass are not known. Serum proteomics were assayed using the SOMAlogic 7K panel.