Connectome: aging research evidence

Associations

1

High-order functional interactions

upin silico1

1 study

Connectome predicts high-order functional interactions in silico.
“differences in high-order functional interactions between age groups can be largely explained by variations in the connectome.”
In silicon = 161
High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model
PLoS computational biologySep 2, 2022

Funding

10 grants since 2018

National Institute on AgingUS$18mNational Institute of Mental HealthUS$4mNIH Office of the DirectorUS$1.9m

Latest

115 papers in 12 months

Imaging NeuroscienceYesterday

Brain anatomy linked to proposed MRI marker in healthy adults

An observational study of 850 healthy young adults and 150 healthy aging participants linked MRI measurements to brain anatomy and the choice of brain regions analyzed.An observational study of 850 healthy young adults and 150 healthy aging participants linked MRI measurements to brain anatomy and the choice of brain regions analyzed.

Cross-sectional · 150 peopleBiomarkers

Paper

bioRxivOct 15

Food perception alone stimulates oviposition through serotonin signaling in Drosophila

Preprint: experiments in fliesSynaptic transmission

Paper

Research SquareOct 8

Human white-matter connections form four reproducible patterns

Four patterns captured most variation in connections across 438 brain regions and were reproducible across repeated scans and independent datasets.Four patterns captured most variation in connections across 438 brain regions and were reproducible across repeated scans and independent datasets.

Preprint: cross-sectional study in peopleAI & data

Paper

arXivOct 7

From the Drosophila Visual Connectome to General-Purpose Computer Vision

Preprint: computational studyAI & data

Paper

arXivOct 6

CoHyFuse: Condition-wise Hypergraph Fusion with Global Connectome in Task-fMRI

Preprint: computational studyBiomarkers

Paper

bioRxivOct 5

Dopamine clearance–cognition link varies by age and structure

In 3,650 adults, elevated modeled dopamine clearance was linked to poorer cognition only with marked structural degradation and within sliding age windows centered…In 3,650 adults, elevated modeled dopamine clearance was linked to poorer cognition only with marked structural degradation and within sliding age windows centered between 56 and 76 years.

Preprint: cohort study of 3,650 peopleMechanisms

Paper

Imaging NeuroscienceOct 2