Concealed mitochondrial DNA mutations

Concealed mitochondrial DNA mutations predict chronological age in humans.

“At a correlative level we find that human age can be predicted from these concealed mutations”

Humans

Large-scale single-cell mapping of concealed mitochondrial ageing

bioRxiv (Cold Spring Harbor Laboratory)·20 Jul 2026Preprint

Chronological age is associated with concealed mitochondrial DNA mutations in humans.

“We find that low-prevalence mutations (in ≤ 1% of assayed cells), concealed from routine bulk sequencing, accumulate markedly with age”

HumansLow-prevalence mutations in ≤ 1% of assayed cells11 proliferative cell types and 5 tissuesn = 311

Large-scale single-cell mapping of concealed mitochondrial ageing

bioRxiv (Cold Spring Harbor Laboratory)·20 Jul 2026Preprint

Concealed mitochondrial DNA mutations are associated with dysfunction-associated gene-expression changes in humans.

“These low-prevalence mutations (unlike mutations tracking larger clones) show limited negative selection and coincide with gene-expression changes marking dysfunction.”

HumansLow-prevalence mutations

Large-scale single-cell mapping of concealed mitochondrial ageing

bioRxiv (Cold Spring Harbor Laboratory)·20 Jul 2026Preprint