The statistical estimate of the difference in decline in planning and task-management skills was minus 0.07 for variant carriers versus noncarriers.The statistical estimate of the difference in decline in planning and task-management skills was minus 0.07 for variant carriers versus noncarriers.
Cohort study of 445 adults aged 90–104, average 3.9 years, against non-ɛ4-carriersPopulations
Limit: Survivor selection may favor unusually resilient ɛ4 carriers, distorting the link with cognitive decline
Each standard-deviation increase in the midlife marker was linked to 0.030 standard deviations faster late-life memory decline during an 11-year follow-up.Each standard-deviation increase in the midlife marker was linked to 0.030 standard deviations faster late-life memory decline during an 11-year follow-up.
Cohort study of 1,515 adults with midlife and late-life blood samples, 11 yearsBiomarkers
Limit: The outcome was declining thinking skills, not dementia onset
In one genetic group, each extra diet-score point was linked to lower relative Alzheimer’s dementia risk over time (hazard ratio 0.82).In one genetic group, each extra diet-score point was linked to lower relative Alzheimer’s dementia risk over time (hazard ratio 0.82).