CMI-MLI

1. CMI-MLI predicts incident cardiovascular disease in humans (HR 1.35, 95% CI 1.15–1.59; per SD increase: HR 1.11, 95% CI 1.04–1.17).

   “Participants in the highest CMI-MLI quartile had a significantly higher risk of incident CVD (HR 1.35, 95% CI 1.15-1.59) than those in the lowest quartile”

   HumansCHARLS participants with baseline CKM stages 0–3; highest versus lowest CMI-MLI quartileMedian 9-year follow-upn = 5,768

   Association of Combined Cardiometabolic and Muscle Impairment Index with Cardiovascular-Kidney-Metabolic Syndrome Progression Among Middle-Aged and Older Adults: A Prospective Two-Cohort Study

   Healthcare (Basel, Switzerland)·1 Oct 2026

More on Incident cardiovascular disease

1. CMI-MLI is associated with advanced cardiovascular-kidney-metabolic syndrome stages in humans.

   “higher CMI-MLI quartiles were significantly associated with advanced CKM stages in both cohorts (p for trend <0.0001).”

   HumansCross-sectional analyses in CHARLS and NHANES

   Association of Combined Cardiometabolic and Muscle Impairment Index with Cardiovascular-Kidney-Metabolic Syndrome Progression Among Middle-Aged and Older Adults: A Prospective Two-Cohort Study

   Healthcare (Basel, Switzerland)·1 Oct 2026

More on Advanced cardiovascular-kidney-metabolic syndrome stages