Clock gene expression PC1 score

Frailty is associated with clock gene expression PC1 score in humans.

“PCA identified a coordinated pattern of clock gene expression, with pre-frail and frail participants exhibiting lower PC1 scores than robust individuals.”

HumansPre-frail and frail participants compared with robust participants; morning measurementperipheral blood mononuclear celln = 82

Chronotype and Peripheral Clock Genes: Association With Frailty and Insomnia in Mexican Older Adults

Aging medicine (Milton (N.S.W))·14 Oct 2026