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CKM staging

Papers on CKM staging

377 papers120 new in 30 days

Friday, November 13

Research Square

Blood and body-size scores linked to cardiovascular risk

In 5,304 Chinese adults, one score was linked to new cardiovascular disease with a hazard ratio of 1.213 per standard-deviation increase.In 5,304 Chinese adults, one score was linked to new cardiovascular disease with a hazard ratio of 1.213 per standard-deviation increase.

Blood cells mingle with dense and sparse clusters of small particles beside a heart and upright, faceless people with varied waist sizes.
Preprint: cohort · 5,304 peopleCardiovascular disease
Paper

Tuesday, November 10

Monday, November 9

AHA Scientific Sessions 2026 Abstract

Heart disease risk staging was weaker at age 80 and older

The framework’s score for distinguishing heart disease death risk was 0.543 at age 80 and older, versus 0.737 at ages 65–79.The framework’s score for distinguishing heart disease death risk was 0.543 at age 80 and older, versus 0.737 at ages 65–79.

Heart cross-section flanked by kidneys and groups of upright, faceless people with gray or white hair and intermixed light and dark blue-green bodies.
Cohort · 21,570 peopleHeart disease
Paper
AHA Scientific Sessions 2026 Abstract

Lower muscle quality linked to higher death risk in US adults

The lowest muscle-quality third had more than twice the odds of advanced cardiovascular-kidney-metabolic syndrome compared with the highest third.The lowest muscle-quality third had more than twice the odds of advanced cardiovascular-kidney-metabolic syndrome compared with the highest third.

Skeletal muscle shifts from dense to sparse fibers, beside clenched and relaxed hands and contrasting dark blue-green and gray hearts and kidneys.
Cohort · 5,594 peopleBiomarkers
Paper
AHA Scientific Sessions 2026 Abstract

Blood proteins help predict progression of linked chronic diseases

A protein-based model scored 0.796 versus 0.731 for a clinical model on a measure of how well it distinguished people who progressed.A protein-based model scored 0.796 versus 0.731 for a clinical model on a measure of how well it distinguished people who progressed.

Blood cells mingle with small folded proteins, one dark among pale forms, beside heart and kidney sections and a group of upright faceless people.
Cohort · 44,107 peopleCirculating proteins
Paper
AHA Scientific Sessions 2026 Abstract

Advanced heart-kidney-metabolic stages share 90 genetic regions

In 391,836 UK Biobank participants, a 90-region genetic core spanned stages 2–4 of the syndrome, while stage 1 differed substantially.In 391,836 UK Biobank participants, a 90-region genetic core spanned stages 2–4 of the syndrome, while stage 1 differed substantially.

Dark blue-green chromosomes share dark bands beside a smaller gray chromosome with pale bands, above heart and kidney cross-sections.
Genetic association · 391,836 peopleCardiovascular-kidney-metabolic syndrome
Paper
AHA Scientific Sessions 2026 Abstract

Urine protein linked to cardiovascular deaths in US adults

A urine protein measure of 10–29 mg/g was linked to 65% higher cardiovascular mortality than values below 10 mg/g in adults without diabetes or cardiovascular disease.A urine protein measure of 10–29 mg/g was linked to 65% higher cardiovascular mortality than values below 10 mg/g in adults without diabetes or cardiovascular disease.

Urine droplets with dense and sparse protein molecules sit beside a fragmented gray heart and an intact dark blue-green heart, respectively.
Cohort · 43,989 peopleBiomarkers
Paper

Saturday, November 7

medRxiv

Heart, kidney and metabolic burden centers on later stages

Stages 3–4 included 15.8% of US adults but accounted for 76% of estimated years lost to premature death attributed to cardiovascular-kidney-metabolic syndrome.Stages 3–4 included 15.8% of US adults but accounted for 76% of estimated years lost to premature death attributed to cardiovascular-kidney-metabolic syndrome.

Survey-weighted prevalence of CKM stages among US adults, NHANES 2005-2023.
Preprint: cross-sectional studyCardiovascular-kidney-metabolic syndrome
Paper
AHA Scientific Sessions 2026 Abstract

Pregnancy diabetes linked to worse heart, kidney and metabolic health

Women with past pregnancy diabetes had a relative risk of 1.55 for the most advanced stage compared with women without that history.Women with past pregnancy diabetes had a relative risk of 1.55 for the most advanced stage compared with women without that history.

A heart with dark damaged patches sits beside a kidney, blood cells, and women, opposite gray women with a smaller intact heart and kidney.
Cross-sectional · 11,181 peopleStage 4 cardiovascular-kidney-metabolic syndrome
Paper
AHA Scientific Sessions 2026 Abstract

Sleep problems’ link to cardiovascular deaths varied by risk

Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.Sleep scores of one and two had adjusted hazard ratios of 0.907 and 1.117 versus zero, relative death-rate measures whose uncertainty ranges included no difference.

A large opened heart sits among upright people, broken crescent moons, and smaller hearts and kidneys with smooth interiors on one side and gray patches…
Cohort · 33,661 peopleCardiovascular disease
Paper
AHA Scientific Sessions 2026 Abstract

High social disadvantage linked to heart risk like mild artery calcium

Cardiovascular event rates were 3.77 per 1,000 person-years with high social disadvantage and no artery calcium, versus 3.12 with mild calcium and high disadvantage.Cardiovascular event rates were 3.77 per 1,000 person-years with high social disadvantage and no artery calcium, versus 3.12 with mild calcium and high disadvantage.

Coronary arteries with clear walls and sparse calcium deposits sit beneath separate groups of upright people, each with a similar share of dark figures.
Cohort · 2,901 peoplePopulations
Paper
AHA Scientific Sessions 2026 Abstract

Heart strain marker linked to cardiovascular death risk

Elevated versus normal levels were linked to an adjusted hazard ratio—a comparison of risk over time—of 1.87 for heart and blood vessel deaths.Elevated versus normal levels were linked to an adjusted hazard ratio—a comparison of risk over time—of 1.87 for heart and blood vessel deaths.

A large heart cross-section surrounded by blood cells and dense dark marker clusters sits beside a smaller gray heart with sparse markers.
Cohort · 12,264 peopleCardiovascular disease
Paper
AHA Scientific Sessions 2026 Abstract

Heart, kidney and metabolic burden linked to later heart risk

An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher…An observational analysis of 2,968 CARDIA participants and 4,294 MESA participants linked accumulated burden to unfavorable heart structure and function and higher cardiovascular event risk.

A thick-walled heart section sits beside kidneys and enlarged fat cells, with a smaller, thinner-walled heart and sparse fat cells nearby.
Cohort studyCardiovascular-kidney-metabolic diseases
Paper