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CKM staging

There are 2 papers on CKM staging in aging research: 2 observational studies in people. The newest story, Nov 9, 2026: “Heart disease risk staging was weaker at age 80 and older”.

Biomarker

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120 new papers in 30 daysSee all 377 papers on CKM staging

“The CKM + age model exhibited C=0.889, indicating an enhancement over age alone (ΔC=+0.031; 95% CI +0.016 to +0.045, p<0.001).”
Discriminatory Performance of Cardiovascular-Kidney-Metabolic Syndrome Staging for Heart Disease Mortality Across the Adult Age SpanAHA Scientific Sessions 2026 abstract2026doi:10.1161/circ.154.suppl_1.6263
  • Humans2

Effects

1

Heart disease mortality discrimination

upin humans1

1 study

  1. CKM staging is linked with better heart disease mortality discrimination in humans (Compared with age alone) (C=0.889; ΔC=+0.031, 95% CI +0.016 to +0.045; p<0.001).

    “The CKM + age model exhibited C=0.889, indicating an enhancement over age alone (ΔC=+0.031; 95% CI +0.016 to +0.045, p<0.001).”

    HumansCompared with age aloneMedian follow-up 4.75 yearsn = 21,570

    Heart disease risk staging was weaker at age 80 and older

    AHA Scientific Sessions 2026 abstract

Associations

1

Heart disease mortality discrimination

mixedin humans1

1 study

  1. CKM staging predicts heart disease mortality discrimination in humans (Age-stratified analysis) (C=0.543 at ≥80 years versus 0.741, 0.707, and 0.737 at 20–49, 50–64, and 65–79 years; interaction p=0.004).

    “discrimination remained robust for the age groups 20-49, 50-64, and 65-79 years (C=0.741, 0.707, and 0.737), but declined significantly at ≥80 years (C=0.543; 95% CI 0.519-0.568).”

    HumansAge-stratified analysisMedian follow-up 4.75 years

    Heart disease risk staging was weaker at age 80 and older

    AHA Scientific Sessions 2026 abstract

Latest

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AHA Scientific Sessions 2026 Abstract

Heart disease risk staging was weaker at age 80 and older

The framework’s score for distinguishing heart disease death risk was 0.543 at age 80 and older, versus 0.737 at ages 65–79.The framework’s score for distinguishing heart disease death risk was 0.543 at age 80 and older, versus 0.737 at ages 65–79.

Cohort · 21,570 peopleHeart disease
Paper
Research Square

Blood and body-size scores linked to cardiovascular risk

In 5,304 Chinese adults, one score was linked to new cardiovascular disease with a hazard ratio of 1.213 per standard-deviation increase.In 5,304 Chinese adults, one score was linked to new cardiovascular disease with a hazard ratio of 1.213 per standard-deviation increase.

Preprint: cohort · 5,304 peopleCardiovascular disease
Paper
AHA Scientific Sessions 2026 Abstract

Lower muscle quality linked to higher death risk in US adults

The lowest muscle-quality third had more than twice the odds of advanced cardiovascular-kidney-metabolic syndrome compared with the highest third.The lowest muscle-quality third had more than twice the odds of advanced cardiovascular-kidney-metabolic syndrome compared with the highest third.

Cohort · 5,594 peopleBiomarkers
Paper
AHA Scientific Sessions 2026 Abstract

Blood proteins help predict progression of linked chronic diseases

A protein-based model scored 0.796 versus 0.731 for a clinical model on a measure of how well it distinguished people who progressed.A protein-based model scored 0.796 versus 0.731 for a clinical model on a measure of how well it distinguished people who progressed.

Cohort · 44,107 peopleCirculating proteins
Paper
AHA Scientific Sessions 2026 Abstract

Advanced heart-kidney-metabolic stages share 90 genetic regions

In 391,836 UK Biobank participants, a 90-region genetic core spanned stages 2–4 of the syndrome, while stage 1 differed substantially.In 391,836 UK Biobank participants, a 90-region genetic core spanned stages 2–4 of the syndrome, while stage 1 differed substantially.

Genetic association · 391,836 peopleCardiovascular-kidney-metabolic syndrome
Paper

See all 377 papers on CKM staging

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