Chronological age
Biomarker1 paper1 finding
- In silico1
Associations
1Geneformer
upin silico1
1 study
Geneformer
upin silico1
Geneformer predicts chronological age in silico.
In silicousing frozen pretrained representations
Single-cell foundation models show task-dependent utility for aging biology research · bioRxiv · 27 Sep 2026 · Preprint
Latest
18DNA methylation variability provides a distinct epigenetic marker of human aging heterogeneity
Combining methylation variance with mean methylation levels improved predictions of all-cause mortality across two independent human cohorts.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Mechanistic biological age clock matches PhenoAge in predicting human mortality
The systems pharmacology model splits biological age into organ axes, revealing that pharmacological drops in inflammation may not translate to expected risk reductions.
Epigenetic puberty index tracks biological aging and adult health risks
A DNA-methylation measure of pubertal development correlates with established epigenetic clocks and predicts mortality and disease in two large adult cohorts.
Organ age acceleration and mortality risk reflect distinct biological processes
Multi-omics clocks across fourteen organs reveal divergent molecular programs and uncover thirteen candidate genes separating age acceleration from mortality.
Electrocardiogram heart age reflects past electrical burden but not future aging pace
Researchers analyzed serial electrocardiograms from over 128,000 patients to distinguish cumulative cardiac aging damage from the rate of future electrical changes.
Speech clocks reflect dementia phenotypes and biological aging markers
A cross-national analysis of Latin American participants connected speech age gaps to epigenetic age, brain clocks, and cognitive decline.
Chronological age prediction does not prove biological age measurement
Researchers show that standard age-trained clocks reflect task-specific statistics rather than true biological aging constructs, limiting how researchers interpret clock gaps and rejuvenation.
Older adults with preserved cognition show slower biological aging and longer telomeres
An observational study in Chile linked perfect Mini-Mental State Examination scores in people over 80 to slower epigenetic clocks and longer estimated telomeres.