cGAMP
Biomarker1 paper3 findings
- Animals1
Effects
3Paralysis
upin mice1
1 study
Paralysis
upin mice1
cGAMP increases paralysis in mice.
Animalsin Enpp1H362A mice
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint
Exploration
downin mice1
1 study
Exploration
downin mice1
cGAMP decreases exploration in mice.
Animalsin mice
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint
Motor coordination
downin mice1
1 study
Motor coordination
downin mice1
cGAMP impairs motor coordination in mice.
Animalsin mice
Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice · bioRxiv · 2 Oct 2026 · Preprint
Latest
2Extracellular cGAMP drives neuroinflammation and premature aging phenotypes in mice
Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain…Loss of the cGAMP-degrading enzyme ENPP1 allows microglia-derived signaling molecules to trigger STING-dependent inflammation across multiple brain cell types.