Centrum semiovale perivascular space volume

Centrum semiovale perivascular space volume decreases cognitive function in humans (2% reduction per 10% change).

“A 10% change in CSO‐PVS volume would estimate a 2% reduction in cognitive score.”

Humansn = 17,771

Computational perivascular space volumes derived from magnetic resonance imaging relate to lower cognitive performance and cognitive decline ‐ A multicentre individual patient data meta‐analysis

AAIC 2025 abstract·25 Dec 2025