Computational perivascular space volumes derived from magnetic resonance imaging relate to lower cognitive performance and cognitive decline ‐ A multicentre individual patient data meta‐analysis

Abstract

Background: Perivascular spaces (PVS), when enlarged, become visible and quantifiable on brain magnetic resonance images (MRI). PVS visibility in MRI has been found to be associated with ageing, hypertension, sleep disorders, and cerebral small vessel disease, but their relationship with cognition in adults remains unclear.