Cellular senescence-associated gene expression

1. mTORopathies are associated with cellular senescence-associated gene expression in humans.

   “Downregulated genes were enriched in oxidative phosphorylation (OXPHOS) and mitochondrial metabolic pathways, whereas upregulated genes were associated with gliogenesis and cellular senescence.”

   HumansmTORopathy brains compared with controlsbrain

   Comprehensive transcriptomic and proteomic profiling of mTOR-related epilepsy

   bioRxiv (Cold Spring Harbor Laboratory)·11 Mar 2026Preprint

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