Cell type-specific proteomic age

1. Cell type-specific proteomic age predicts lung cancer in humans (58% higher lung cancer risk).

   “Beyond neurodegeneration, respiratory cell aging identified smokers at 58% higher lung cancer risk, and myeloid aging identified normoglycemic individuals at higher diabetes risk.”

   Humansin smokers

   Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

   bioRxiv : the preprint server for biology·12 Feb 2026Preprint

More on Lung cancer

1. Cell type-specific proteomic age raises the risk of Alzheimer's disease in humans (threefold).

   “Moreover, extreme astrocyte aging increased AD risk in APOE4/4 carriers threefold, while youthful astrocytes strikingly reduced risk.”

   Humansin APOE4/4 carriers

   Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

   bioRxiv : the preprint server for biology·12 Feb 2026Preprint

More on Alzheimer's disease

1. Cell type-specific proteomic age raises the risk of amyotrophic lateral sclerosis in humans (hazard ratio = 12.7).

   “Amyotrophic lateral sclerosis (ALS) showed the strongest association with skeletal myocyte aging (hazard ratio = 12.7 for extreme accelerated versus youthful aging).”

   Humansextreme accelerated versus youthful aging

   Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

   bioRxiv : the preprint server for biology·12 Feb 2026Preprint

More on Amyotrophic lateral sclerosis