CD25+ mast cells

1. CD25+ mast cells increase SASP index in humans (M = 3884 vs 2599).

   “Patients with CD25+ mast cells, a sign of active disease state, had significantly higher SASP values (M = 3884) compared to patients with inactive disease (M = 2599; t(30.99)=-3.1461, p < 0.05).”

   Humansactive vs inactive ISM

   A Senescence Associated Secretory Phenotype (SASP) in Indolent Systemic Mastocytosis Compared to Healthy Controls

   GSA 2025 abstract·31 Dec 2025

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