CASPASE-1 activation

1. Nicotinamide mononucleotide decreases CASPASE-1 activation in mouse cells.

   “restoration of NAD+ level by supplementation with nicotinamide mononucleotide abrogated the FK866-mediated caspase-1 cleavage”

   CellsFK866-treated BMDMs

   Intracellular NAD⁺ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation

   Frontiers in immunology·20 Dec 2021

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1. FK866 increases CASPASE-1 activation in mouse cells.

   “FK866 facilitated robust caspase-1 activation in BMDMs in the presence of NLRP3-activating signals such as ATP and nigericin”

   Cellsin the presence of ATP or nigericin

   Intracellular NAD⁺ Depletion Confers a Priming Signal for NLRP3 Inflammasome Activation

   Frontiers in immunology·20 Dec 2021

More on FK866