Cardiometabolic-frailty index

1. Cardiometabolic-frailty index raises the risk of cardiometabolic multimorbidity in humans (HR 5.86, 95% CI 4.23–8.11).

   “incident CMM occurred in 464 of 7,326 participants over 4 years; Q4 versus Q1 HR was 5.86 (95% CI 4.23–8.11).”

   HumansQ4 vs Q14 yearsn = 7,326

   Associations of baseline, cumulative, and dynamic trajectories of the cardiometabolic-frailty index with incident cardiovascular disease: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS)

   Research Square·25 Aug 2026Preprint

More on Cardiometabolic multimorbidity

1. Cardiometabolic-frailty index raises the risk of cardiovascular disease in humans (HR 1.72, 95% CI 1.47–2.01).

   “Compared with the lowest quartile (Q1), the highest baseline CMIFI quartile (Q4) was associated with a 1.72-fold increased risk of CVD (95% CI 1.47–2.01; P for trend < 0.001) after full adjustment.”

   Humanshighest baseline CMIFI quartile (Q4) vs lowest quartile (Q1)9 yearsn = 7,748

   Associations of baseline, cumulative, and dynamic trajectories of the cardiometabolic-frailty index with incident cardiovascular disease: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS)

   Research Square·25 Aug 2026Preprint

More on Cardiovascular disease