Calculated free testosterone
4 papers study it11 more mention it2 findings
- Humans3
Upstream
1Age
downin humans1
1 study
Age
downin humans1
Age decreases calculated free testosterone in humans (7.7 ± 1.9 versus 8.8 ± 2.2 and 10.4 ±3.1 ng/dL, p < 0.001).
“values of calculated free testosterone were lower in the older tertile (7.7 ± 1.9 versus 8.8 ± 2.2 and 10.4 ±3.1 ng/dL; p < 0.001)”
Humansmalesn = 136
Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men
Archives of endocrinology and metabolismAug 26, 2025
Associations
1Bone mineral content
downin humans1
1 study
Bone mineral content
downin humans1
Calculated free testosterone is associated with bone mineral content in humans.
“decreases in cFT (but not total T) levels were associated with larger decreases in lumbar spine BMC”
Humanslumbar spine12 yearsmalesn = 676
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchMar 14, 2022
Latest
2 papers in 12 monthsExperimental Physiology
Long-term endurance running training and testosterone daily variation in ageing men; a comparative cross-sectional study
Cross-sectional study of 45 peoplePopulations
Archives of Endocrinology and Metabolism
Association of age and insulin resistance with sex hormone-binding globulin levels in healthy men
Cross-sectional study of 136 peopleSex hormone signaling (estrogen, androgen)
Journal of Diabetes Investigation
Distinct patterns of hypogonadism in a cross-sectional study of Malaysian men with type 2 diabetes mellitus: The role of insulin resistance, visceral adiposity, and aging
Cross-sectional study of 360 peopleHypogonadism
Aging Clinical and Experimental Research
Compared to total serum testosterone, calculated free testosterone has a stronger association with lean mass, muscle strength, power, and physical function in older men
Cross-sectional study of 557 peopleFree testosterone
Current Opinion in Endocrinology, Diabetes, and Obesity
Use of calculated free testosterone in men: advantages and limitations
ReviewFree testosterone
Physiology & Behavior
Reproductive hormone levels, androgen receptor CAG repeat length and their longitudinal relationships with decline in cognitive subdomains in men: The European Male Ageing Study
Cohort study of 1,827 peoplePopulations
Journal of Bone and Mineral Research
Modest Changes in Sex Hormones During Early and Middle Adulthood Affect Bone Mass and Size in Healthy Men: A Prospective Cohort Study
Cohort study of 999 peopleBones and joints
American Journal of Men's Health
The Epidemiological Characteristics of Late-Onset Hypogonadism in Chinese Middle-Aged and Elderly Men: Two Cross-Sectional Studies in the Same Community
Study in peoplePopulations
The Journal of Clinical Endocrinology and Metabolism
Serum Testosterone is Inversely and Sex Hormone-binding Globulin is Directly Associated with All-cause Mortality in Men
Study in peopleBiomarkers