Phosphate
Intervention1 paper2 findings
- Animals1
Outcomes
2Mortality
upin mice1Very low certainty
1 study
Mortality
upin mice1Very low certainty
Phosphate increases mortality in mice.
Animalsin TMEM174 KO mice1.2%
TMEM174 deficiency shortens lifespan and stiffens vessels in mice · Scientific reports · 2 Oct 2026
Vascular calcification
upin mice1Very low certainty
1 study
Vascular calcification
upin mice1Very low certainty
Phosphate increases vascular calcification in mice.
Animalsin TMEM174 KO mice1.2%
TMEM174 deficiency shortens lifespan and stiffens vessels in mice · Scientific reports · 2 Oct 2026
Latest
1TMEM174 deficiency shortens lifespan and stiffens vessels in mice
Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification…Knocking out the proximal tubule protein in mice shortened survival, whereas altering dietary phosphate intake regulated vascular calcification, stiffness, and mortality.