Brain-derived tau oligomers

1. Brain-derived tau oligomers induce cell death in cells.

   “Additionally, we treated SH‐SY5Y neuroblastoma cells and human synaptosomes isolated from cortex of control samples with these BDTOs and assessed their cytotoxicity and synaptotoxicity, respectively.”

   Cellsisolated from converters vs non-converters

   Brain‐Derived Tau Oligomers in Circulating Extracellular Vesicles as Predictive Biomarkers for Alzheimer's Disease Conversion

   AAIC 2025 abstract·8 Jan 2026

1. Brain-derived tau oligomers predict Alzheimer's disease.

   “We identified distinct PK digestion patterns, morphology, and toxicity between BDTOs from converters and non‐converters.”

   Humansin longitudinal plasma samplesplasma

   Brain‐Derived Tau Oligomers in Circulating Extracellular Vesicles as Predictive Biomarkers for Alzheimer's Disease Conversion

   AAIC 2025 abstract·8 Jan 2026

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