Brain atrophy components

1. Brain atrophy components predict disease progression in humans.

   “CCL‐NMF provided a richer representation and demonstrated improved predictive performance across various outcomes, including AD, cardiovascular disease markers, and disease progression”

   Humansbrainn = 48,949

   Dominant Trajectories of Aging‐related Brain Atrophy Identified in 48,949 Individuals via a coupled Cross‐sectional and Longitudinal Non‐negative Matrix Factorization

   AAIC 2025 abstract·24 Dec 2025

1. Brain atrophy components are associated with cognitive decline in humans.

   “CCL‐NMF identified seven distinct brain atrophy components associated with Alzheimer's disease (AD), cognitive decline, and cardiovascular risk factors.”

   Humansaging-related brain atrophybrainn = 48,949

   Dominant Trajectories of Aging‐related Brain Atrophy Identified in 48,949 Individuals via a coupled Cross‐sectional and Longitudinal Non‐negative Matrix Factorization

   AAIC 2025 abstract·24 Dec 2025

1. Brain atrophy components are associated with Alzheimer's disease in humans.

   “CCL‐NMF identified seven distinct brain atrophy components associated with Alzheimer's disease (AD), cognitive decline, and cardiovascular risk factors.”

   Humansaging-related brain atrophybrainn = 48,949

   Dominant Trajectories of Aging‐related Brain Atrophy Identified in 48,949 Individuals via a coupled Cross‐sectional and Longitudinal Non‐negative Matrix Factorization

   AAIC 2025 abstract·24 Dec 2025

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