There is 1 paper on biological age minus chronological age in aging research: 1 observational study in people. The newest story, Oct 12, 2026: “Biological aging linked to syndrome in middle-aged and older Chinese”.
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“higher biological age (per 1 year higher in delta of ages) was associated with more severe frailty at admission (OR: 1.053, 95 % CI:1.012-1.096) in patients who had a CIRS score of <12”
Frailty change from admission to discharge
no changein humans1
Biological age minus chronological age was not clearly linked with frailty change from admission to discharge in humans.
“The delta of ages was not associated with frailty change from admission to discharge.”
Humansn = 1,187
Experimental gerontology
Frailty
no changein humans1
Biological age minus chronological age was not clearly linked with frailty in humans (CIRS score > 12).
“not in patients with a CIRS score >12”
HumansCIRS score > 12n = 1,187
Experimental gerontology
Frailty
upin humans1OR 1.053
Biological age minus chronological age is associated with frailty in humans (CIRS score < 12) (OR 1.053, 95% CI 1.012-1.096).
“higher biological age (per 1 year higher in delta of ages) was associated with more severe frailty at admission (OR: 1.053, 95 % CI:1.012-1.096) in patients who had a CIRS score of <12”
HumansCIRS score < 12n = 1,187
Experimental gerontology
Cancer incidence
upin humans1
Biological age minus chronological age is associated with cancer incidence in humans (Hazard increased 0.4% per 1-year increase).
“and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001).”
Humans11-year follow-up
Clinical interventions in aging
Stroke incidence
upin humans1
Biological age minus chronological age is associated with stroke incidence in humans (Hazard increased 1.6% per 1-year increase).
“and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001).”
Humans11-year follow-up
Clinical interventions in aging
Heart disease incidence
upin humans1
Biological age minus chronological age is associated with heart disease incidence in humans (Hazard increased 1.3% per 1-year increase).
“and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001).”
Humans11-year follow-up
Clinical interventions in aging
Diabetes mellitus incidence
upin humans1
Biological age minus chronological age is associated with diabetes mellitus incidence in humans (Hazard increased 4.2% per 1-year increase).
“and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001).”
Humans11-year follow-up
Clinical interventions in aging
Hypertension incidence
upin humans1
Biological age minus chronological age is associated with hypertension incidence in humans (Hazard increased 2.5% per 1-year increase).
“and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001).”
Humans11-year follow-up
Clinical interventions in aging
Mortality
upin humans1
Biological age minus chronological age is associated with mortality in humans (Mortality hazard increased 1.6% per 1-year increase; 1.5% in men and 2.0% in women).
“For every 1 year increase of the calculated BA and chronological age difference, the hazard ratio for mortality significantly increased by 1.6%”
Humans11-year follow-up
Clinical interventions in aging
Biological age acceleration was 1.61 years higher in Chinese middle-aged and older adults with circadian syndrome than in those without it, after adjustment for other…Biological age acceleration was 1.61 years higher in Chinese middle-aged and older adults with circadian syndrome than in those without it, after adjustment for other factors.