Clinical Interventions in Aging · Mar 20, 2018

Biological age as a health index for mortality and major age-related disease incidence in Koreans: National Health Insurance Service - Health screening 11-year follow-up study

By Kang YG, Suh E, Lee JW et al.

PURPOSE: A comprehensive health index is needed to measure an individual's overall health and aging status and predict the risk of death and age-related disease incidence, and evaluate the effect of a health management program. The purpose of this study is to demonstrate the validity of estimated biological age (BA) in relation to all-cause mortality and age-related disease incidence based on National Sample Cohort database. PATIENTS AND METHODS: This study was based on National Sample Cohort database of the National Health Insurance Service - Eligibility database and the National Health Insurance Service - Medical and Health Examination database of the year 2002 through 2013. BA model was developed based on the National Health Insurance Service - National Sample Cohort (NHIS - NSC) database and Cox proportional hazard analysis was done for mortality and major age-related disease incidence. RESULTS: For every 1 year increase of the calculated BA and chronological age difference, the hazard ratio for mortality significantly increased by 1.6% (1.5% in men and 2.0% in women) and also for hypertension, diabetes mellitus, heart disease, stroke, and cancer incidence by 2.5%, 4.2%, 1.3%, 1.6%, and 0.4%, respectively (p<0.001). CONCLUSION: Estimated BA by the developed BA model based on NHIS - NSC database is expected to be used not only as an index for assessing health and aging status and predicting mortality and major age-related disease incidence, but can also be applied to various health care fields.

doi.org/10.2147/cia.s157014 Open access PubMed 29593385 Biomarkers