Beta cell function

Biomarker

3 papers1 finding

  • Human trial1
  • Humans2

Upstream

1

Time

downin humans1

1 study
  1. time decreases beta cell function in humans (pslope=<0.001).

    “However, C5 showed the strongest decline in beta cell function (Adaptation Index, pslope=<0.001)”

    Humansin cluster 5 (high visceral and liver fat, high insulin resistance) at-risk individualsn = 148

    The Natural History of Type 2 Diabetes Varies between Clinical Subphenotypes of At-Risk Individuals

    ADA Scientific Sessions 2026 abstract6 Jun 2026

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Diabetologia

Genetic background shapes cell aging and diabetes in male mice

Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.Male mice carrying the same diabetes-linked mutation developed diabetes on a mixed genetic background, but maintained normal blood sugar on another background.

Experiments in miceMechanisms