Baseline-anchored z-score intrinsic capacity composite

Baseline-anchored z-score intrinsic capacity composite increases responsiveness to intervention-related intrinsic capacity change in humans (Baseline-anchored SRM 0.62–0.71 versus concurrent SRM ≈ 0).

“the concurrent specification was insensitive (SRM ≈ 0), whereas baseline-anchoring showed moderate responsiveness (0.62-0.71).”

Human trialBaseline-anchored versus concurrent standardization of the z-score composite12 weeksn = 59

Toward Standardization of Intrinsic Capacity Assessment: A Methodological Comparison of the Responsiveness of Composite Scoring Methods

Gerontology·13 Oct 2026