AUC to detect PET-Aβ positivity

1. pTau217/Aβ42 ratio improves AUC to detect PET-Aβ positivity in humans.

   “Using the pTau217/Aβ42 ratio significantly improved the area under the curve (AUC) over pTau217 alone to detect PET‐Aβ positivity in both the ADCC and ITTC”

   Humansin AD continuum cohort (ADCC) and intention to treat cohort (ITTC)

   Combining Lumipulse pTau217 and Aβ42 as confirmatory tests for Aβ pathology prior to DMT

   AAIC 2025 abstract·7 Jan 2026

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