Annualized change in biological age

1. Annualized change in biological age mediates mortality in humans (5.05% of the association mediated).

   “About 5.05% of the association between HLS and mortality was mediated by ΔMDAge/year.”

   HumansMediation of the association between HLS and mortality

   Lifestyles modify the biological aging process: evidence from multiple cohorts

   American journal of epidemiology·3 Jul 2025

1. Healthy lifestyle is associated with annualized change in biological age in humans (Adjusted β −0.38 (95% CI −0.49 to −0.28) for HLS 5 versus 0).

   “Compared to individuals with HLS of 0, increasing HLS was associated with decreased level of ΔMDAge/year”

   HumansHLS of 5 compared with HLS of 0 in the Taiwan MJ cohortn = 143,823

   Lifestyles modify the biological aging process: evidence from multiple cohorts

   American journal of epidemiology·3 Jul 2025

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