What does the research say about amyloid-positive status?

Amyloid-positive status

There are 2 papers on amyloid-positive status in aging research: 2 observational studies in people. The newest story, Nov 4, 2026: “Smell test scores linked to later mild cognitive impairment”.

Biomarker

2 papers study it2 more mention it2 findings

1 new paper in 30 daysSee all 4 papers on amyloid-positive status

“CN A+ participants had significantly lower odor identification performance than CN A- participants, with no evidence of cohort heterogeneity.”

Olfactory Function in Preclinical Alzheimer's Disease: A Multi-Cohort StudymedRxiv2026doi:10.64898/2026.11.03.26367202

Humans2

Associations

Odor identification performance

downin humans1

1 study

Amyloid-positive status is associated with odor identification performance in humans (cognitively normal; amyloid-positive versus amyloid-negative).
“CN A+ participants had significantly lower odor identification performance than CN A- participants, with no evidence of cohort heterogeneity.”
Humanscognitively normal; amyloid-positive versus amyloid-negativen = 257
Smell test scores linked to later mild cognitive impairment
medRxivNov 4, 2026Preprint

Short-chain fatty acids

downin humans1

1 study

Short-chain fatty acids are associated with amyloid-positive status in humans (cognitively unimpaired at risk for Alzheimer's disease).
“Fecal acetate, propionate, and butyrate levels were reduced in females and in participants with amyloid‐positive status.”
Humanscognitively unimpaired at risk for Alzheimer's diseasestool
Fecal levels of short‐chain fatty acids and prominent bacterial taxa involved in their production are inversely associated with amyloid‐positive status
AAIC 2025 abstractDec 24, 2025

Latest

4 papers in 12 months

medRxivNov 4

Smell test scores linked to later mild cognitive impairment

Among cognitively normal older adults, each 10-percentage-point higher smell identification score was linked to a 16% lower hazard of later mild cognitive impairment.Among cognitively normal older adults, each 10-percentage-point higher smell identification score was linked to a 16% lower hazard of later mild cognitive impairment.

Preprint: cohort · 250 peopleMild cognitive impairment