Alpha-ketoglutarate-to-succinate ratio

1. Alpha-ketoglutarate increases alpha-ketoglutarate-to-succinate ratio in humans.

   “oral α-KG supplementation significantly increased intraocular α-KG levels and the α-KG-to-succinate ratio (P < 0.05)”

   Human trialphase 0 cohort undergoing sequential cataract surgeryoral

   Multi-omics liquid biopsy identifies mitochondrial dysfunction in geographic atrophy and supports the longevity-associated metabolite α-ketoglutarate as a therapeutic strategy

   medRxiv : the preprint server for health sciences·19 Mar 2026Preprint

More on Alpha-ketoglutarate