Alpha-ketoglutarate dehydrogenase activity

1. 4-hydroxy-2-nonenal inhibits alpha-ketoglutarate dehydrogenase activity in rat cells.

   “alpha-Ketoglutarate dehydrogenase is highly susceptible to 4-hydroxy-2-nonenal inactivation in vitro.”

   Cellsin vitro

   Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

   Proceedings of the National Academy of Sciences of the United States of America·8 Jun 1999

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