ALPHA-1 antitrypsin

1 paper3 findings

Humans1

Associations

3

Cardiovascular mortality

upin humans1

1 study

ALPHA-1 antitrypsin raises the risk of cardiovascular mortality in humans.
“Risk of cancer, cardiovascular and 'other' deaths were all elevated.”
Humans10.9 years
Elevated alpha-1 antitrypsin and C-reactive protein: association on all-cause and cause-specific mortality in older adults
GeroScience29 Oct 2025

Cancer mortality

upin humans1

1 study

ALPHA-1 antitrypsin raises the risk of cancer mortality in humans.
“Risk of cancer, cardiovascular and 'other' deaths were all elevated.”
Humans10.9 years
Elevated alpha-1 antitrypsin and C-reactive protein: association on all-cause and cause-specific mortality in older adults
GeroScience29 Oct 2025

Mortality

upin humans1

1 study

ALPHA-1 antitrypsin raises the risk of mortality in humans (aHR 1.53, 95% CI 1.28-1.65).
“Individuals in highest AAT decile had a 53% higher likelihood of mortality during follow-up (aHR 1.53, 95% CI 1.28-1.65).”
Humans10.9 years
Elevated alpha-1 antitrypsin and C-reactive protein: association on all-cause and cause-specific mortality in older adults
GeroScience29 Oct 2025

Latest

1 in 12 months

medRxiv24 Sep

The Alpha-1 Antitrypsin Z-allele associates with sarcopenia in the UK Biobank

Preprint: cohort study of 487,207 peopleSarcopenia

GeroScience29 Oct

Elevated alpha-1 antitrypsin and C-reactive protein: association on all-cause and cause-specific mortality in older adults

Cohort study of 11,879 peopleC-reactive protein

Science Advances10 Oct

Hyperactive 20S proteasome enhances proteostasis and ERAD in C. elegans via degradation of intrinsically disordered proteins

Experiments in wormsUbiquitin–proteasome system