1:"/_next/static/immutable/chunks/2bx4f2cm_tcc8.js" 2:"/_next/static/immutable/chunks/219zopmodkwiw.js" 3:"/_next/static/immutable/chunks/0585vjyycbw68.js" 4:"/_next/static/immutable/chunks/0zqhf0jr6lk4m.js" 5:"/_next/static/immutable/chunks/3je2wpe3xesz7.js" 6:"/_next/static/immutable/chunks/2-n-529re-gos.js" 7:"HTTPAccessFallbackBoundary" 8:I[768017,["$1","$2","$3","$4","$5","$6"],"$7"] 19:I[168027,["$1","$2","$3","$4","$5","$6"],"default",1] :HL["/_next/static/immutable/chunks/0sm8-chvetc42.css","style"] :HL["/_next/static/immutable/chunks/30em4u5lv6lia.css","style"] :HL["/_next/static/immutable/media/3a11180d498b75c0-s.p.0ghexb8m2rs_v.woff2","font",{"crossOrigin":"","type":"font/woff2"}] b:T10b4,{"@context":"https://schema.org","@graph":[{"@type":"NewsMediaOrganization","@id":"https://agingresearch.news/#organization","name":"AgingResearch.News","alternateName":["Aging Research News"],"url":"https://agingresearch.news","logo":"https://agingresearch.news/logo.png","description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","slogan":"Every new aging paper, judged on evidence, never on fame.","foundingDate":"2026-10-02","founder":{"@type":"Person","@id":"https://agingresearch.news/person/boris-djordjevic#person","name":"Boris Djordjevic","jobTitle":"Editor, AgingResearch.News","url":"https://agingresearch.news/person/boris-djordjevic","sameAs":["https://x.com/longevityboris"],"worksFor":{"@id":"https://agingresearch.news/#organization"}},"parentOrganization":{"@type":"Organization","name":"Paperfoot AI Pte. Ltd.","address":{"@type":"PostalAddress","addressCountry":"SG"}},"publishingPrinciples":"https://agingresearch.news/status#standards","correctionsPolicy":"https://agingresearch.news/status#standards","ethicsPolicy":"https://agingresearch.news/status#standards","verificationFactCheckingPolicy":"https://agingresearch.news/status#standards","noBylinesPolicy":"https://agingresearch.news/status#standards","actionableFeedbackPolicy":"https://agingresearch.news/status#standards","contactPoint":{"@type":"ContactPoint","contactType":"editorial","url":"https://agingresearch.news/contact"},"knowsAbout":[{"@type":"Thing","name":"Aging","sameAs":"https://en.wikipedia.org/wiki/Ageing"},{"@type":"Thing","name":"Geroscience","sameAs":"https://en.wikipedia.org/wiki/Geroscience"},{"@type":"Thing","name":"Life extension","sameAs":"https://en.wikipedia.org/wiki/Life_extension"},{"@type":"Thing","name":"Cellular senescence","sameAs":"https://en.wikipedia.org/wiki/Cellular_senescence"},{"@type":"Thing","name":"Epigenetic clock","sameAs":"https://en.wikipedia.org/wiki/Epigenetic_clock"},{"@type":"Thing","name":"mTOR","sameAs":"https://en.wikipedia.org/wiki/MTOR"},{"@type":"Thing","name":"Rapamycin","sameAs":"https://en.wikipedia.org/wiki/Sirolimus"},{"@type":"Thing","name":"Cellular reprogramming","sameAs":"https://en.wikipedia.org/wiki/Reprogramming"},{"@type":"Thing","name":"NAD+","sameAs":"https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide"},{"@type":"Thing","name":"Sirtuins","sameAs":"https://en.wikipedia.org/wiki/Sirtuin"},{"@type":"Thing","name":"Mitochondria","sameAs":"https://en.wikipedia.org/wiki/Mitochondria"},{"@type":"Thing","name":"Calorie restriction","sameAs":"https://en.wikipedia.org/wiki/Calorie_restriction"},{"@type":"Thing","name":"GLP-1 receptor agonists","sameAs":"https://en.wikipedia.org/wiki/GLP-1_receptor_agonist"},{"@type":"Thing","name":"Inflammaging","sameAs":"https://en.wikipedia.org/wiki/Inflammaging"},{"@type":"Thing","name":"Brain aging","sameAs":"https://en.wikipedia.org/wiki/Aging_brain"},{"@type":"Thing","name":"Biological aging","sameAs":"https://en.wikipedia.org/wiki/Senescence"},{"@type":"Thing","name":"Geroprotectors","sameAs":"https://en.wikipedia.org/wiki/Geroprotector"},{"@type":"Thing","name":"Biomarkers of aging","sameAs":"https://en.wikipedia.org/wiki/Biomarkers_of_aging"},{"@type":"Thing","name":"Gerontology","sameAs":"https://en.wikipedia.org/wiki/Gerontology"},{"@type":"Thing","name":"Longevity","sameAs":"https://en.wikipedia.org/wiki/Longevity"},{"@type":"Thing","name":"Bioinformatics","sameAs":"https://en.wikipedia.org/wiki/Bioinformatics"},{"@type":"Thing","name":"Biotechnology","sameAs":"https://en.wikipedia.org/wiki/Biotechnology"},{"@type":"Thing","name":"Health policy","sameAs":"https://en.wikipedia.org/wiki/Health_policy"}],"sameAs":["https://x.com/agingbrief","https://www.linkedin.com/company/agingresearch-news"]},{"@type":"WebSite","@id":"https://agingresearch.news/#website","url":"https://agingresearch.news","name":"AgingResearch.News","alternateName":["Aging Research News"],"description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","inLanguage":"en","publisher":{"@id":"https://agingresearch.news/#organization"}}]}12:X 15:[["children",{"s":"__PAGE__","d":{"r":"$L16","p":false,"v":null}}]] 13:[["children",{"s":{"n":"key","t":"d","k":"akt2-phosphorylation-at-thr309-and-ser474","s":[]},"d":{"r":"$L14","p":false,"v":"$12"},"c":"$Q15"}]] 10:[["children",{"s":"biomarker","d":{"r":"$L11","p":false,"v":"$12"},"c":"$Q13"}],["sheet",{"s":"__DEFAULT__","d":{"r":"$L17","p":false,"v":null}}]] 0:{"P":null,"c":["","biomarker","akt2-phosphorylation-at-thr309-and-ser474"],"q":"","i":false,"t":{"t":{"s":"","h":16,"d":{"r":["$","$L8","c",{"notFound":[[["$","link","0",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/0sm8-chvetc42.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}],["$","link","1",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/30em4u5lv6lia.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}],["$","script","script-0",{"src":"/_next/static/immutable/chunks/2bx4f2cm_tcc8.js","async":true,"nonce":"$undefined"}],["$","script","script-1",{"src":"/_next/static/immutable/chunks/219zopmodkwiw.js","async":true,"nonce":"$undefined"}],["$","script","script-2",{"src":"/_next/static/immutable/chunks/0585vjyycbw68.js","async":true,"nonce":"$undefined"}],["$","script","script-3",{"src":"/_next/static/immutable/chunks/0zqhf0jr6lk4m.js","async":true,"nonce":"$undefined"}],["$","script","script-4",{"src":"/_next/static/immutable/chunks/3je2wpe3xesz7.js","async":true,"nonce":"$undefined"}],["$","script","script-5",{"src":"/_next/static/immutable/chunks/2-n-529re-gos.js","async":true,"nonce":"$undefined"}]],["$","html",null,{"lang":"en","className":"_0coOsG_className ujwUxa_variable FJdxoa_variable Q67yJW_variable","data-release":"72e98c5c","suppressHydrationWarning":true,"children":[["$","head",null,{"children":[["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var m=localStorage.getItem(\"arn.me\");if(m)document.documentElement.dataset.me=m}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var s=sessionStorage,n=performance.getEntriesByType(\"navigation\")[0],q;try{q=JSON.parse(s.getItem(\"arn.arrivals\")||\"[]\")}catch(e){}if(!Array.isArray(q))q=[];q.push({path:location.pathname,referrer:document.referrer,search:location.search,started:s.getItem(\"arn.visit\")===\"1\",again:!!n&&(n.type===\"reload\"||n.type===\"back_forward\")});s.setItem(\"arn.arrivals\",JSON.stringify(q.slice(-20)));s.setItem(\"arn.visit\",\"1\")}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var d=document.documentElement,o=false,s=null;try{s=sessionStorage;o=s.getItem(\"arn.offers\")===\"off\"}catch(e){}if(!o){var u=(new URLSearchParams(location.search).get(\"utm_source\")||\"\").trim().toLowerCase(),h=\"\",c=\"\",m=null;try{h=new URL(document.referrer).hostname.toLowerCase().replace(/^www\\./,\"\")}catch(e){}try{c=String(document.cookie||\"\")}catch(e){}c.split(\";\").forEach(function(x){var p=x.trim().split(\"=\");if(p[0]===\"arn_app\")m=/^[A-Z]{3}$/.test(p[1]||\"\")?p[1]:\"\"});o=[\"chatgpt\",\"chatgpt.com\",\"chat.openai.com\"].indexOf(u)>=0||[\"chatgpt.com\",\"chat.openai.com\",\"oaiusercontent.com\"].some(function(x){return h===x||h.slice(-x.length-1)===\".\"+x})||((m!==null||[\"arn-ios\",\"arn-android\"].indexOf(u)>=0)&&[\"USA\"].indexOf(m||\"\")<0);if(o&&s)try{s.setItem(\"arn.offers\",\"off\")}catch(e){}}if(o)d.dataset.offers=\"off\";try{if(localStorage.getItem(\"arn.billing\")===\"appstore\")d.dataset.proOffers=\"off\"}catch(e){}}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var v=(new URLSearchParams(location.search).get(\"via\")||\"\").trim().toLowerCase();if(/^(?:[a-z]{1,12}-)?[a-z0-9]{8}$/.test(v))document.documentElement.dataset.joinOff=location.pathname}catch(e){}"}}],"$L9","$La"]}],["$","body",null,{"className":"min-h-dvh bg-paper font-sans text-ink","children":[["$","a",null,{"href":"#content","className":"skip-link","children":["$","span",null,{"data-t":"nav.skip","lang":"$undefined","children":["$","i",null,{"children":"Skip to content"}]}]}],["$","script",null,{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$b"}}],"$Lc","$Ld","$Le"]}]]}]],"children":["$0:t:t:d:r:props:notFound:0","$Lf"]}],"p":false,"v":null},"c":"$Q10"},"h":{"r":"$L18","p":false,"v":null}},"m":"$undefined","G":["$19",["$L1a","$L1b"]],"S":false,"r":"$undefined","s":"$undefined","a":"$undefined","l":"$undefined","p":"$undefined","d":"$undefined"} 1c:I[684230,["$1","$2","$3","$4","$5","$6"],"MeProvider"] 1d:"/_next/static/immutable/chunks/1pqw5_miehegc.js" 1e:"/_next/static/immutable/chunks/2_5el-kceykl9.js" 1f:"/_next/static/immutable/chunks/0zu0z3u0cdqrb.js" 20:"/_next/static/immutable/chunks/3qq5e-rv3q0yt.js" 21:"/_next/static/immutable/chunks/1y6m3rf1myyz2.js" 22:I[432748,["$1","$2","$3","$4","$5","$6","$1d","$1e","$1f","$20","$21"],"Unplaced"] 23:"/_next/static/immutable/chunks/23o2a4_qx8ipm.js" 24:I[675689,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"Rail"] 25:I[435939,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"SiteHeader"] 26:I[443567,["$1","$2","$3","$4","$5","$6","$1d","$1e","$1f","$20","$21"],"NotFoundSearch"] 27:I[522016,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],""] 29:I[149277,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"FoundingBar"] 2a:I[432384,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"TrialOfferSheet"] 2b:I[36861,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"SharedBy"] 2d:I[936821,["$1","$2","$3","$4","$5","$6"],"AuthHost"] 2e:I[188415,["$1","$2","$3","$4","$5","$6"],"BottomTabBar"] 2f:I[233785,["$1","$2","$3","$4","$5","$6"],"FeedTracker"] 30:I[696255,["$1","$2","$3","$4","$5","$6"],"NavMemory"] 31:I[124213,["$1","$2","$3","$4","$5","$6"],"PageviewBeacon"] 32:I[401529,["$1","$2","$3","$4","$5","$6"],"VitalsBeacon"] 39:"$Sreact.fragment" 3a:I[339756,["$1","$2","$3","$4","$5","$6"],"default"] 3b:I[837457,["$1","$2","$3","$4","$5","$6"],"default"] 3d:I[897367,["$1","$2","$3","$4","$5","$6"],"OutletBoundary"] 3f:"ViewportBoundary" 40:I[897367,["$1","$2","$3","$4","$5","$6"],"$3f"] 42:"MetadataBoundary" 43:I[897367,["$1","$2","$3","$4","$5","$6"],"$42"] 44:"$Sreact.suspense" c:["$","$L1c",null,{"children":[[[],[["$","$L22",null,{"children":["$","div",null,{"className":"frame","data-wide":"$undefined","children":[["$","$L24",null,{"hint":"$undefined","updatesAt":"2026-10-21T03:32:00+01:00"}],["$","div",null,{"className":"frame-column min-w-0","children":[[["$","$L25",null,{"hint":"$undefined"}],["$","div",null,{"id":"content","tabIndex":-1,"className":"outline-none"}]],["$","main",null,{"className":"min-w-0 px-(--col-pad) lg:pb-16 pt-4 md:pt-5","children":[["$","header",null,{"className":"bleed flex items-end justify-between gap-6 border-b border-rule px-(--col-pad) pb-3","children":[["$","div",null,{"className":"min-w-0","children":["$undefined",["$","h1",null,{"className":"headline text-[22px] leading-[1.15] font-extrabold tracking-[-0.02em] text-ink","children":["$","span",null,{"data-t":"not-found.title","lang":"$undefined","children":["$","i",null,{"children":"Page not found"}]}]}],"$undefined"]}],"$undefined"]}],["$","p",null,{"className":"mt-4 text-[15px] leading-[1.4] text-pretty text-ink-soft","children":["$","span",null,{"data-t":"not-found.line","lang":"$undefined","children":["$","i",null,{"children":"The link may be old or mistyped."}]}]}],["$","$L26",null,{}],["$","ul",null,{"className":"mt-6","children":[["$","li","/",{"children":["$","$L27",null,{"href":"/","prefetch":false,"className":"bleed flex min-h-12 items-center border-b border-rule px-(--col-pad) text-[15px] font-bold transition-colors duration-[120ms] hover:bg-hover active:bg-pressed","children":["$","span",null,{"data-t":"nav.home","lang":"$undefined","children":["$","i",null,{"children":"Home"}]}]}]}],["$","li","/latest",{"children":["$","$L27",null,{"href":"/latest","prefetch":false,"className":"bleed flex min-h-12 items-center border-b border-rule px-(--col-pad) text-[15px] font-bold transition-colors duration-[120ms] hover:bg-hover active:bg-pressed","children":["$","span",null,{"data-t":"nav.latest","lang":"$undefined","children":["$","i",null,{"children":"Latest"}]}]}]}],["$","li","/topics",{"children":["$","$L27",null,{"href":"/topics","prefetch":false,"className":"bleed flex min-h-12 items-center border-b border-rule px-(--col-pad) text-[15px] font-bold transition-colors duration-[120ms] hover:bg-hover active:bg-pressed","children":["$","span",null,{"data-t":"nav.topics","lang":"$undefined","children":["$","i",null,{"children":"Topics"}]}]}]}]]}]]}],"$L28",["$","$L29",null,{"until":"2026-11-30T23:59:59.000Z"}],["$","$L2a",null,{}]]}],["$","$L2b",null,{}],"$L2c"]}]}],"$c:props:children:0:0"]],"$undefined",["$","$L2d",null,{"oneTapClientId":"1014590465548-acrir82hrkhsm9kpku98fp77435bh7qo.apps.googleusercontent.com"}],["$","$L2e",null,{}],["$","$L2f",null,{}],["$","$L30",null,{}]]}] d:["$","$L31",null,{}] e:["$","$L32",null,{}] 35:T10b4,{"@context":"https://schema.org","@graph":[{"@type":"NewsMediaOrganization","@id":"https://agingresearch.news/#organization","name":"AgingResearch.News","alternateName":["Aging Research News"],"url":"https://agingresearch.news","logo":"https://agingresearch.news/logo.png","description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","slogan":"Every new aging paper, judged on evidence, never on fame.","foundingDate":"2026-10-02","founder":{"@type":"Person","@id":"https://agingresearch.news/person/boris-djordjevic#person","name":"Boris Djordjevic","jobTitle":"Editor, AgingResearch.News","url":"https://agingresearch.news/person/boris-djordjevic","sameAs":["https://x.com/longevityboris"],"worksFor":{"@id":"https://agingresearch.news/#organization"}},"parentOrganization":{"@type":"Organization","name":"Paperfoot AI Pte. Ltd.","address":{"@type":"PostalAddress","addressCountry":"SG"}},"publishingPrinciples":"https://agingresearch.news/status#standards","correctionsPolicy":"https://agingresearch.news/status#standards","ethicsPolicy":"https://agingresearch.news/status#standards","verificationFactCheckingPolicy":"https://agingresearch.news/status#standards","noBylinesPolicy":"https://agingresearch.news/status#standards","actionableFeedbackPolicy":"https://agingresearch.news/status#standards","contactPoint":{"@type":"ContactPoint","contactType":"editorial","url":"https://agingresearch.news/contact"},"knowsAbout":[{"@type":"Thing","name":"Aging","sameAs":"https://en.wikipedia.org/wiki/Ageing"},{"@type":"Thing","name":"Geroscience","sameAs":"https://en.wikipedia.org/wiki/Geroscience"},{"@type":"Thing","name":"Life extension","sameAs":"https://en.wikipedia.org/wiki/Life_extension"},{"@type":"Thing","name":"Cellular senescence","sameAs":"https://en.wikipedia.org/wiki/Cellular_senescence"},{"@type":"Thing","name":"Epigenetic clock","sameAs":"https://en.wikipedia.org/wiki/Epigenetic_clock"},{"@type":"Thing","name":"mTOR","sameAs":"https://en.wikipedia.org/wiki/MTOR"},{"@type":"Thing","name":"Rapamycin","sameAs":"https://en.wikipedia.org/wiki/Sirolimus"},{"@type":"Thing","name":"Cellular reprogramming","sameAs":"https://en.wikipedia.org/wiki/Reprogramming"},{"@type":"Thing","name":"NAD+","sameAs":"https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide"},{"@type":"Thing","name":"Sirtuins","sameAs":"https://en.wikipedia.org/wiki/Sirtuin"},{"@type":"Thing","name":"Mitochondria","sameAs":"https://en.wikipedia.org/wiki/Mitochondria"},{"@type":"Thing","name":"Calorie restriction","sameAs":"https://en.wikipedia.org/wiki/Calorie_restriction"},{"@type":"Thing","name":"GLP-1 receptor agonists","sameAs":"https://en.wikipedia.org/wiki/GLP-1_receptor_agonist"},{"@type":"Thing","name":"Inflammaging","sameAs":"https://en.wikipedia.org/wiki/Inflammaging"},{"@type":"Thing","name":"Brain aging","sameAs":"https://en.wikipedia.org/wiki/Aging_brain"},{"@type":"Thing","name":"Biological aging","sameAs":"https://en.wikipedia.org/wiki/Senescence"},{"@type":"Thing","name":"Geroprotectors","sameAs":"https://en.wikipedia.org/wiki/Geroprotector"},{"@type":"Thing","name":"Biomarkers of aging","sameAs":"https://en.wikipedia.org/wiki/Biomarkers_of_aging"},{"@type":"Thing","name":"Gerontology","sameAs":"https://en.wikipedia.org/wiki/Gerontology"},{"@type":"Thing","name":"Longevity","sameAs":"https://en.wikipedia.org/wiki/Longevity"},{"@type":"Thing","name":"Bioinformatics","sameAs":"https://en.wikipedia.org/wiki/Bioinformatics"},{"@type":"Thing","name":"Biotechnology","sameAs":"https://en.wikipedia.org/wiki/Biotechnology"},{"@type":"Thing","name":"Health policy","sameAs":"https://en.wikipedia.org/wiki/Health_policy"}],"sameAs":["https://x.com/agingbrief","https://www.linkedin.com/company/agingresearch-news"]},{"@type":"WebSite","@id":"https://agingresearch.news/#website","url":"https://agingresearch.news","name":"AgingResearch.News","alternateName":["Aging Research News"],"description":"AgingResearch.News is the superintelligence for aging research. It reads every new paper, weighs the evidence, cites every claim and fits a feed to your work.","inLanguage":"en","publisher":{"@id":"https://agingresearch.news/#organization"}}]}f:["$","html",null,{"lang":"en","className":"_0coOsG_className ujwUxa_variable FJdxoa_variable Q67yJW_variable","data-release":"72e98c5c","suppressHydrationWarning":true,"children":[["$","head",null,{"children":[["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var m=localStorage.getItem(\"arn.me\");if(m)document.documentElement.dataset.me=m}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var s=sessionStorage,n=performance.getEntriesByType(\"navigation\")[0],q;try{q=JSON.parse(s.getItem(\"arn.arrivals\")||\"[]\")}catch(e){}if(!Array.isArray(q))q=[];q.push({path:location.pathname,referrer:document.referrer,search:location.search,started:s.getItem(\"arn.visit\")===\"1\",again:!!n&&(n.type===\"reload\"||n.type===\"back_forward\")});s.setItem(\"arn.arrivals\",JSON.stringify(q.slice(-20)));s.setItem(\"arn.visit\",\"1\")}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var d=document.documentElement,o=false,s=null;try{s=sessionStorage;o=s.getItem(\"arn.offers\")===\"off\"}catch(e){}if(!o){var u=(new URLSearchParams(location.search).get(\"utm_source\")||\"\").trim().toLowerCase(),h=\"\",c=\"\",m=null;try{h=new URL(document.referrer).hostname.toLowerCase().replace(/^www\\./,\"\")}catch(e){}try{c=String(document.cookie||\"\")}catch(e){}c.split(\";\").forEach(function(x){var p=x.trim().split(\"=\");if(p[0]===\"arn_app\")m=/^[A-Z]{3}$/.test(p[1]||\"\")?p[1]:\"\"});o=[\"chatgpt\",\"chatgpt.com\",\"chat.openai.com\"].indexOf(u)>=0||[\"chatgpt.com\",\"chat.openai.com\",\"oaiusercontent.com\"].some(function(x){return h===x||h.slice(-x.length-1)===\".\"+x})||((m!==null||[\"arn-ios\",\"arn-android\"].indexOf(u)>=0)&&[\"USA\"].indexOf(m||\"\")<0);if(o&&s)try{s.setItem(\"arn.offers\",\"off\")}catch(e){}}if(o)d.dataset.offers=\"off\";try{if(localStorage.getItem(\"arn.billing\")===\"appstore\")d.dataset.proOffers=\"off\"}catch(e){}}catch(e){}"}}],["$","script",null,{"dangerouslySetInnerHTML":{"__html":"try{var v=(new URLSearchParams(location.search).get(\"via\")||\"\").trim().toLowerCase();if(/^(?:[a-z]{1,12}-)?[a-z0-9]{8}$/.test(v))document.documentElement.dataset.joinOff=location.pathname}catch(e){}"}}],"$L33","$L34"]}],["$","body",null,{"className":"min-h-dvh bg-paper font-sans text-ink","children":[["$","a",null,{"href":"#content","className":"skip-link","children":["$","span",null,{"data-t":"nav.skip","lang":"$undefined","children":["$","i",null,{"children":"Skip to content"}]}]}],["$","script",null,{"type":"application/ld+json","dangerouslySetInnerHTML":{"__html":"$35"}}],"$L36","$L37","$L38"]}]]}] 11:["$","$39","c",{"children":[null,["$","$L3a",null,{"parallelRouterKey":"children","error":"$undefined","errorStyles":"$undefined","errorScripts":"$undefined","template":["$","$L3b",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$undefined","forbidden":"$undefined","unauthorized":"$undefined"}]]}] 14:["$","$39","c",{"children":[null,["$","$L3a",null,{"parallelRouterKey":"children","error":"$undefined","errorStyles":"$undefined","errorScripts":"$undefined","template":["$","$L3b",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$undefined","forbidden":"$undefined","unauthorized":"$undefined"}]]}] 16:["$","$39","c",{"children":["$L3c",[["$","script","script-0",{"src":"/_next/static/immutable/chunks/23o2a4_qx8ipm.js","async":true,"nonce":"$undefined"}],["$","script","script-1",{"src":"/_next/static/immutable/chunks/2_5el-kceykl9.js","async":true,"nonce":"$undefined"}],["$","script","script-2",{"src":"/_next/static/immutable/chunks/0zu0z3u0cdqrb.js","async":true,"nonce":"$undefined"}],["$","script","script-3",{"src":"/_next/static/immutable/chunks/3qq5e-rv3q0yt.js","async":true,"nonce":"$undefined"}],["$","script","script-4",{"src":"/_next/static/immutable/chunks/1y6m3rf1myyz2.js","async":true,"nonce":"$undefined"}]],["$","$L3d",null,{"children":"$@3e"}]]}] 17:["$","$39","c",{"children":[null,null,null]}] 18:["$","$39","h",{"children":[null,["$","$L40",null,{"children":"$L41"}],["$","$L43",null,{"children":[["$","div",null,{"hidden":true,"children":["$","$44",null,{"name":"Next.Metadata","children":"$L45"}]}],"$L46"]}],["$","meta",null,{"name":"next-size-adjust","content":""}]]}] 1a:["$","link","0",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/0sm8-chvetc42.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}] 1b:["$","link","1",{"rel":"stylesheet","href":"/_next/static/immutable/chunks/30em4u5lv6lia.css","precedence":"next","crossOrigin":"$undefined","nonce":"$undefined"}] 47:"/_next/static/immutable/chunks/1x4rycuvxh-fm.js" 48:I[408821,["$1","$2","$3","$4","$5","$6","$47"],"default"] 4a:I[194008,["$1","$2","$3","$4","$5","$6"],"LangMarks"] 12:C 36:["$","$L1c",null,{"children":[["$","$L3a",null,{"parallelRouterKey":"children","error":"$48","errorStyles":[],"errorScripts":[["$","script","script-0",{"src":"/_next/static/immutable/chunks/1x4rycuvxh-fm.js","async":true,"nonce":"$undefined"}]],"template":["$","$L3b",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$c:props:children:0:1","forbidden":"$undefined","unauthorized":"$undefined"}],["$","$L3a",null,{"parallelRouterKey":"sheet","error":"$48","errorStyles":"$36:props:children:0:props:errorStyles","errorScripts":"$36:props:children:0:props:errorScripts","template":["$","$L3b",null,{}],"templateStyles":"$undefined","templateScripts":"$undefined","notFound":"$undefined","forbidden":"$undefined","unauthorized":"$undefined"}],["$","$L2d",null,{"oneTapClientId":"1014590465548-acrir82hrkhsm9kpku98fp77435bh7qo.apps.googleusercontent.com"}],["$","$L2e",null,{}],["$","$L2f",null,{}],["$","$L30",null,{}]]}] 37:["$","$L31",null,{}] 38:["$","$L32",null,{}] 49:T628,(()=>{try{var T=[["es-MX"],["pt-PT"],["en-US"],["en-GB","IE AU NZ"],["zh-Hans"],["zh-Hant"],["ja"],["ko"],["es-ES"],["it"],["de-DE"],["nl-NL"],["pt-BR"],["fr-FR"],["ru"]],k="307afffb",d=document,h=d.documentElement,m=function g(a,b){for(let c=0;c=0)return b[a][0];null===e&&(e=b[a][0])}}if(null!==e)return e}return null},l=null,c=d.cookie.match(/(?:^|; )arn_lang=([^;]*)/);if(c){var v=decodeURIComponent(c[1]),i=v.lastIndexOf(".");if(/^(web|app|detected)$/.test(v.slice(i+1)))l=m([v.slice(0,i)],T)}if(!l){l=m(navigator.languages,T)||"en-US";d.cookie="arn_lang="+l+".detected;path=/;max-age=31536000;samesite=lax"}h.setAttribute("data-lang",l);if(l==="en-US")return;var p=l+"."+k+"\n",s=localStorage.getItem("arn.i18n"),e=d.createElement("style");if(s&&s.indexOf(p)===0){e.textContent=s.slice(p.length);d.head.appendChild(e);return}var f=()=>h.removeAttribute("data-lw"),n=d.createElement("link");h.setAttribute("data-lw","");setTimeout(f,1500);e.textContent="[data-lw] [data-t],[data-lw] [data-trich]{visibility:hidden}";d.head.appendChild(e);n.rel="stylesheet";n.href="/i18n/"+l+"."+k+".css";n.setAttribute("blocking","render");n.onerror=f;n.onload=()=>{f();try{localStorage.setItem("arn.i18n",p+Array.from(n.sheet.cssRules,r=>r.cssText).join("\n"))}catch{}};d.head.appendChild(n)}catch{}})()a:[["$","script",null,{"dangerouslySetInnerHTML":{"__html":"$49"}}],["$","$L4a",null,{}]] 4b:T628,(()=>{try{var T=[["es-MX"],["pt-PT"],["en-US"],["en-GB","IE AU NZ"],["zh-Hans"],["zh-Hant"],["ja"],["ko"],["es-ES"],["it"],["de-DE"],["nl-NL"],["pt-BR"],["fr-FR"],["ru"]],k="307afffb",d=document,h=d.documentElement,m=function g(a,b){for(let c=0;c=0)return b[a][0];null===e&&(e=b[a][0])}}if(null!==e)return e}return null},l=null,c=d.cookie.match(/(?:^|; )arn_lang=([^;]*)/);if(c){var v=decodeURIComponent(c[1]),i=v.lastIndexOf(".");if(/^(web|app|detected)$/.test(v.slice(i+1)))l=m([v.slice(0,i)],T)}if(!l){l=m(navigator.languages,T)||"en-US";d.cookie="arn_lang="+l+".detected;path=/;max-age=31536000;samesite=lax"}h.setAttribute("data-lang",l);if(l==="en-US")return;var p=l+"."+k+"\n",s=localStorage.getItem("arn.i18n"),e=d.createElement("style");if(s&&s.indexOf(p)===0){e.textContent=s.slice(p.length);d.head.appendChild(e);return}var f=()=>h.removeAttribute("data-lw"),n=d.createElement("link");h.setAttribute("data-lw","");setTimeout(f,1500);e.textContent="[data-lw] [data-t],[data-lw] [data-trich]{visibility:hidden}";d.head.appendChild(e);n.rel="stylesheet";n.href="/i18n/"+l+"."+k+".css";n.setAttribute("blocking","render");n.onerror=f;n.onload=()=>{f();try{localStorage.setItem("arn.i18n",p+Array.from(n.sheet.cssRules,r=>r.cssText).join("\n"))}catch{}};d.head.appendChild(n)}catch{}})()34:[["$","script",null,{"dangerouslySetInnerHTML":{"__html":"$4b"}}],["$","$L4a",null,{}]] 41:[["$","meta","0",{"charSet":"utf-8"}],["$","meta","1",{"name":"viewport","content":"width=device-width, initial-scale=1, viewport-fit=cover"}],["$","meta","2",{"name":"theme-color","content":"#ffffff","media":"(prefers-color-scheme: light)"}],["$","meta","3",{"name":"theme-color","content":"#242424","media":"(prefers-color-scheme: dark)"}],["$","meta","4",{"name":"color-scheme","content":"light dark"}]] 4c:"LanguageSwitcher" 4d:I[596701,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"$4c"] 28:["$","footer",null,{"className":"mt-16 border-t border-rule sm:mt-20 lg:hidden","children":["$","nav",null,{"aria-labelledby":"footer-name","className":"flex flex-wrap items-center gap-x-3.5 px-4 py-2 text-[13px] text-muted","children":[["$","span",null,{"id":"footer-name","className":"sr-only","children":["$","span",null,{"data-t":"nav.footer","lang":"$undefined","children":["$","i",null,{"children":"Footer"}]}]}],[["$","$L27","/connect",{"href":"/connect","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":["$","span",null,{"data-t":"footer.assistants","lang":"$undefined","children":["$","i",null,{"children":"AI assistants"}]}]}],["$","$L27","/compare",{"href":"/compare","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":["$","span",null,{"data-t":"footer.compare","lang":"$undefined","children":["$","i",null,{"children":"Compare"}]}]}],["$","$L27","/privacy",{"href":"/privacy","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":["$","span",null,{"data-t":"footer.privacy","lang":"$undefined","children":["$","i",null,{"children":"Privacy"}]}]}],["$","$L27","/terms",{"href":"/terms","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":["$","span",null,{"data-t":"footer.terms","lang":"$undefined","children":["$","i",null,{"children":"Terms"}]}]}],["$","$L27","/contact",{"href":"/contact","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":["$","span",null,{"data-t":"footer.contact","lang":"$undefined","children":["$","i",null,{"children":"Contact"}]}]}],["$","$L27","/feeds",{"href":"/feeds","className":"flex min-h-11 items-center transition-colors duration-[120ms] hover:text-ink","children":["$","span",null,{"data-t":"footer.rss","lang":"$undefined","children":["$","i",null,{"children":"RSS"}]}]}]],["$","a",null,{"href":"https://x.com/agingbrief","target":"_blank","rel":"noopener","title":"@agingbrief","className":"inline-flex items-center gap-1.5 min-h-11 transition-colors duration-[120ms] hover:text-ink","children":[["$","svg",null,{"viewBox":"0 0 1200 1227","aria-hidden":true,"className":"shrink-0 size-[11px]","fill":"currentColor","children":["$","path",null,{"d":"M714.163 519.284L1160.89 0H1055.03L667.137 450.887L357.328 0H0L468.492 681.821L0 1226.37H105.866L515.491 750.218L842.672 1226.37H1200L714.137 519.284H714.163ZM569.165 687.828L521.697 619.934L144.011 79.6944H306.615L611.412 515.685L658.88 583.579L1055.08 1150.3H892.476L569.165 687.854V687.828Z"}]}],["$","span",null,{"data-t":"footer.follow-x","lang":"$undefined","children":["$","i",null,{"children":"Follow on X"}]}]]}],["$","$L4d",null,{"className":"min-h-11"}],["$","span",null,{"children":["© ",2026," ","AgingResearch.News"]}]]}]}] 4e:I[545892,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"SidebarSearch"] 4f:I[43816,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"StickyRail"] 50:I[27054,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"JoinCard"] 51:I[892174,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"HideOn"] 52:I[605500,["$1","$2","$3","$4","$5","$6","$23","$1e","$1f","$20","$21"],"Image"] 2c:["$","aside",null,{"aria-labelledby":"sidebar-name","className":"sidebar hidden lg:block","children":[["$","span",null,{"id":"sidebar-name","className":"sr-only","children":["$","span",null,{"data-t":"nav.sidebar","lang":"$undefined","children":["$","i",null,{"children":"Sidebar"}]}]}],["$","$L4e",null,{}],["$","$L4f",null,{"className":"space-y-3.5 pt-2 pb-10","children":[["$","$L50",null,{"methods":{"google":true,"apple":true},"trialDays":null}],["$","$L51",null,{"section":"/news","children":["$","section",null,{"aria-labelledby":"rail-news","className":"module","children":[["$","div",null,{"className":"module-head","children":[["$","h2",null,{"id":"rail-news","className":"module-title","children":["$","span",null,{"data-t":"nav.news","lang":"$undefined","children":["$","i",null,{"children":"News"}]}]}],["$","$L27",null,{"href":"/news","className":"module-more","children":[["$","span",null,{"aria-hidden":true,"children":["$","span",null,{"data-t":"sidebar.see-all","lang":"$undefined","children":["$","i",null,{"children":"See all"}]}]}],["$","span",null,{"className":"sr-only","children":["$","span",null,{"data-t":"sidebar.see-all-news","lang":"$undefined","children":["$","i",null,{"children":"See all news"}]}]}]]}]]}],[["$","a","433",{"href":"https://www.genengnews.com/topics/omics/secrets-of-oldest-land-animals-194-year-lifespan-revealed-with-epigenetics/","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Jonathan, the 194-year-old tortoise, shows stable epigenetic regulation of metabolism and DNA repair"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":["$","span",null,{"data-t":"news-kind.research","lang":"$undefined","children":["$","i",null,{"children":"Research"}]}]}],["$","span",null,{"className":"min-w-0","children":["GEN"," +7"]}]]}]]}],["$","$L52",null,{"src":"/fig/news-2056/821ac05e.jpg","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}],["$","a","2128",{"href":"https://www.thelancet.com/journals/landig/article/PIIS2589-7500(26)00079-8/fulltext","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"FAHR-Face AI model captures biological aging and disease-related death risk from photographs"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":["$","span",null,{"data-t":"news-kind.research","lang":"$undefined","children":["$","i",null,{"children":"Research"}]}]}],["$","span",null,{"className":"min-w-0","children":["The Lancet Digital Health"," +2"]}]]}]]}],["$","$L52",null,{"src":"/fig/news-11571/11ba809e.webp","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}],["$","a","2192",{"href":"https://www.fightaging.org/archives/2026/10/cellular-senescence-in-liver-aging/","target":"_blank","rel":"noopener","className":"module-row grid grid-cols-[minmax(0,1fr)_auto] items-start gap-3","children":[["$","span",null,{"className":"min-w-0","children":[["$","span",null,{"className":"block text-[15px] leading-[1.25] font-bold tracking-[-0.005em] text-ink","children":"Mouse liver zonation erodes by 18 months alongside rising cellular senescence"}],["$","span",null,{"className":"mt-1 flex items-start gap-1.5 text-[13px] leading-5 text-muted","children":[["$","span",null,{"title":"$undefined","className":"tag","children":["$","span",null,{"data-t":"news-kind.research","lang":"$undefined","children":["$","i",null,{"children":"Research"}]}]}],["$","span",null,{"className":"min-w-0","children":["Fight Aging!",false]}]]}]]}],["$","$L52",null,{"src":"/img/news-2192/9fb025a3.jpg","alt":"","width":48,"height":48,"sizes":"48px","loading":"lazy","draggable":false,"className":"size-12 rounded-lg bg-paper-deep object-cover"}]]}]]]}]}],["$","$L51",null,{"section":"/trials","children":["$","section",null,{"aria-labelledby":"rail-trials","className":"module","children":["$L53",["$L54","$L55","$L56"]]}]}],"$L57","$L58","$L59"]}]]}] 5a:T5d5,(function(c){try{var d=document.documentElement,i,j,K=/^[a-z0-9-]{1,40}$/,own=function(o,k){return Object.prototype.hasOwnProperty.call(o,k)};for(i=0;i

Akt2 phosphorylation at Thr309 and Ser474

Latest

Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats

Related