Age-related plasma metabolome, lipidome, and proteome differences

mitochondrial haplotype is associated with age-related plasma metabolome, lipidome, and proteome differences in rats (50%-80% of differences were mitochondrial-haplotype specific).

“50%-80% were mt-haplotype specific, occurring in either OKC-HETB or OKC-HETW rats but not both.”

AnimalsOKC-HETB/W rats with Brown Norway or Wistar Kyoto mitochondrial haplotypesplasmamale and females

Mitochondrial-Haplotype Influences Plasma Metabolome, Lipidome, and Proteome in a Sex Specific Manner in the Genetically Heterogenous OKC-HETB /W Rat

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·22 May 2026