AD-signature cortical thickness

1. Deep sleep increases AD-signature cortical thickness in humans (β 0.12 (95% CI 0.05 to 0.19)).

   “β deep sleep percentage per 1‐SD increase = 0.12 (95%CI, 0.05 to 0.19, p = 0.006)”

   Humansbrainn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer's Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·7 Jan 2026

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1. Rem sleep latency decreases AD-signature cortical thickness in humans (β -0.14 (95% CI -0.21 to -0.07)).

   “β REM sleep latency per 1‐SD increase = ‐0.14 (95%CI, ‐0.21 to ‐0.07, p< 0.001); while inverse pattern was observed for deep sleep percentage”

   Humansbrainn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer's Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·7 Jan 2026

More on Rem sleep latency

1. Light sleep decreases AD-signature cortical thickness in humans (standardized β -0.12 [95% CI -0.19 to -0.05]).

   “Greater light sleep percentage and longer REM sleep latency were independently associated with thinner cortex in AD‐signature regions: standardized β light sleep percentage per 1‐SD increase = ‐0.12”

   Humansbrainn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer's Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·7 Jan 2026

More on Light sleep

1. Sleep duration decreases AD-signature cortical thickness in humans (β = -0.23, 95% CI -0.41, -0.04).

   “nighttime sleep duration>8 hours ( β = ‐0.23, 95%CI ‐0.41, ‐0.04), longer TIB ( β = ‐0.09, 95% CI ‐0.17, ‐0.02) and awakening length ( β = ‐0.12, 95% CI ‐0.20, ‐0.04) with thinner cortex in AD‐signature regions”

   Humanscompared to participants who slept 6-8 hoursbrainn = 703

   Objective sleep quality and MRI biomarkers of Alzheimer’s Disease in a diverse cohort of older adults

   AAIC 2025 abstract·23 Dec 2025

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1. Internal perceived control increases AD-signature cortical thickness in humans.

   “Greater internal control related to greater baseline cortical thickness for individuals of Caribbean Hispanic ancestry only.”

   HumansCaribbean Hispanic ancestry only

   Perceived Control, Brain Health, and Cognitive Reserve: Assessing Longitudinal Resilience Mechanisms in Diverse Older Adults

   AAIC 2025 abstract·23 Dec 2025

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1. Deep sleep percentage increases AD-signature cortical thickness in humans (β = 0.12, 95% CI 0.05 to 0.19).

   “while inverse pattern was observed for deep sleep percentage: β deep sleep percentage per 1‐SD increase = 0.12 (95%CI, 0.05 to 0.19, p = 0.006)”

   Humansn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer’s Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·23 Dec 2025

More on Deep sleep percentage

1. REM sleep latency decreases AD-signature cortical thickness in humans (β = -0.14, 95% CI -0.21 to -0.07).

   “β REM sleep latency per 1‐SD increase = ‐0.14 (95%CI, ‐0.21 to ‐0.07, p <0.001)”

   Humansn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer’s Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·23 Dec 2025

More on REM sleep latency

1. Light sleep percentage decreases AD-signature cortical thickness in humans (standardized β = -0.12, 95% CI -0.19 to -0.05).

   “Greater light sleep percentage and longer REM sleep latency were independently associated with thinner cortex in AD‐signature regions: standardized β light sleep percentage per 1‐SD increase = ‐0.12 [95% confidence interval (95%CI), ‐0.19 to ‐0.05”

   Humansn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer’s Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·23 Dec 2025

More on Light sleep percentage

1. AD-signature cortical thickness lowers the risk of dementia in humans (HR 0.48 [0.38, 0.61]).

   “‘AD‐signature’ cortical thickness (HR: 0.48 [0.38, 0.61])”

   Humansin SCD individualsn = 324

   Prediction of progression to dementia in individuals with subjective cognitive decline

   AAIC 2025 abstract·24 Dec 2025

More on Dementia

1. Female sex is associated with AD-signature cortical thickness in humans.

   “and had greater cortical thickness in AD signature areas”

   Humanscognitively unimpairedbrain

   Sex differences in imaging biomarkers of Alzheimer’s pathology, neurodegeneration, and vascular injury in a diverse cohort of late middle‐aged adults

   AAIC 2025 abstract·23 Dec 2025