Light sleep percentage

1. Light sleep percentage decreases AD-signature cortical thickness in humans (standardized β = -0.12, 95% CI -0.19 to -0.05).

   “Greater light sleep percentage and longer REM sleep latency were independently associated with thinner cortex in AD‐signature regions: standardized β light sleep percentage per 1‐SD increase = ‐0.12 [95% confidence interval (95%CI), ‐0.19 to ‐0.05”

   Humansn = 636

   Sleep macro‐architecture, nocturnal hypoxemia, and Alzheimer’s Disease‐related MRI patterns among diverse older adults

   AAIC 2025 abstract·23 Dec 2025

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