AD-like EEG signature score

dual APOE-ε4/PICALM G-allele carrier status is associated with AD-like EEG signature score in humans (A+P+: 0.393±0.167; N: 0.296±0.154; A+P-: 0.285±0.143; mean ± SD).

“In the genetic-risk cohort, scores were highest in A+P+ participants (0.393±0.167) relative to N (0.296±0.154) and A+P- (0.285±0.143; subject-level mean ± SD).”

HumansCognitively healthy dual APOE-ε4/PICALM G-allele carriers compared with neutral-risk non-carriers and APOE-ε4-only carriers; exploratory association without AD pathology or conversion ground truth

Cross-cohort transfer of clinical Alzheimer's EEG signatures to cognitively healthy APOE-ε4 and PICALM rs3851179 risk carriers using differentiable logic gate networks

Computers in biology and medicine·15 Oct 2026